发明公开
EP0487270A2 HIV protease inhibitors having polyether substituents
失效
HIV-Proteaseinhibitoren mit Polyether-Substituenten。
- 专利标题： HIV protease inhibitors having polyether substituents
- 专利标题（中）： HIV-Proteaseinhibitoren mit Polyether-Substituenten。
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申请号： EP91310590.4申请日： 1991-11-15
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公开(公告)号： EP0487270A2公开(公告)日： 1992-05-27
- 发明人: Graham, Samuel L. , Hungate, Randall W. , Huff, Joel R. , Lyle, Terry A. , Young, Steven D. , Britcher, Susan F. , Scholz, Thomas H. , Payne, Linda S. , Dorsey, Bruce D.
- 申请人： MERCK & CO. INC.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： MERCK & CO. INC.
- 当前专利权人： MERCK & CO. INC.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Thompson, John Dr.
- 优先权： US615683 19901119; US747156 19910816
- 主分类号： C07C271/22
- IPC分类号： C07C271/22 ; A61K31/27 ; C07C323/60 ; C07F9/40 ; A61K31/66
摘要：
Polyether derivatives of the form,
A-G-B-B-J
wherein G is a dipeptide isostere substituted with a polyether, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of DIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
A-G-B-B-J
wherein G is a dipeptide isostere substituted with a polyether, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of DIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
公开/授权文献
- EP0487270A3 HIV protease inhibitors having polyether substituents 公开/授权日：1992-11-25
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