发明公开
- 专利标题： Naphthoic acid derivative
- 专利标题（中）： Naphtoesäure - 衍生金融工具。
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申请号： EP91120553.2申请日： 1991-11-29
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公开(公告)号： EP0492178A2公开(公告)日： 1992-07-01
- 发明人: Sekine, Yasuo , Yamaura, Tetsuaki , Nishimura, Masato, Fuji Rebio Hachiojiryo , Kojima, Eri , Emoto, Yasuko , Higashide, Yasushi
- 申请人： FUJIREBIO INC.
- 申请人地址： 6-7, Shimoochiai 4-chome Shinjuku-ku Tokyo 161 JP
- 专利权人： FUJIREBIO INC.
- 当前专利权人： FUJIREBIO INC.
- 当前专利权人地址： 6-7, Shimoochiai 4-chome Shinjuku-ku Tokyo 161 JP
- 代理机构： Kraus, Walter, Dr.
- 优先权： JP330004/90 19901130
- 主分类号： C07D333/18
- IPC分类号： C07D333/18 ; C07D207/12 ; C07D295/12 ; C07D213/32 ; C07D213/38 ; C07D211/46 ; C07D213/30 ; C07D307/38 ; C07D401/12 ; A61K31/38 ; A61K31/40
摘要：
A naphthoic acid derivative represented by the following general formula or a salt thereof:
wherein R i , R 2 and R 3 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkanoyloxy-lower alkyl group or an aralkyloxy group;
R 4 is a hydrogen atom or a lower alkyl group;
R 5 is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaromatic group;
X is a group
a cycloalkylene group, a bivalent nitrogen-containing heterocyclic group, or a group
-R 8 - NH- or -NH-R 8 , where R 6 and R 7 are each a hydrogen atom or a lower alkyl group and R 8 is a cycloalkylene group, or R 6 and R 7 , together with R 4 , may form an alkylene group of 1-3 carbon atoms;
Y is -S(O)p-, -(CH 2 ) n - or -0-;
Z is a substituted or unsubstituted alkylene group or a single bond;
ℓ is an integer of 0-4;
m is an integer of 0-8;
n is 0 or 1;
p is an integer of 0-2; and
g is 0 or 1.
The compound is useful as an antiallergic agent.
wherein R i , R 2 and R 3 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkanoyloxy-lower alkyl group or an aralkyloxy group;
R 4 is a hydrogen atom or a lower alkyl group;
R 5 is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaromatic group;
X is a group
a cycloalkylene group, a bivalent nitrogen-containing heterocyclic group, or a group
-R 8 - NH- or -NH-R 8 , where R 6 and R 7 are each a hydrogen atom or a lower alkyl group and R 8 is a cycloalkylene group, or R 6 and R 7 , together with R 4 , may form an alkylene group of 1-3 carbon atoms;
Y is -S(O)p-, -(CH 2 ) n - or -0-;
Z is a substituted or unsubstituted alkylene group or a single bond;
ℓ is an integer of 0-4;
m is an integer of 0-8;
n is 0 or 1;
p is an integer of 0-2; and
g is 0 or 1.
The compound is useful as an antiallergic agent.
公开/授权文献
- EP0492178B1 Naphthoic acid derivative 公开/授权日：1995-10-04
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