发明公开
- 专利标题： Novel cholesterol lowering compounds
- 专利标题（中）： 胆固醇
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申请号： EP92304187.5申请日： 1992-05-08
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公开(公告)号： EP0512865A2公开(公告)日： 1992-11-11
- 发明人: Parsons, William H. , Biftu, Tesfaye , Acton III, John J. , Bugianesi, Robert L. , Berger, Gregory D. , Burk, Robert M. , Girotra, Narindar N. , Ponpipom, Mitree M. , Kuo, Chan-Hwa , Chiang, Yuan-Ching P. , Marquis, Robert W., Jr. , Dufresne, Claude , Plevyak, Sandra P. , Santini, Conrad , Whiting, Lori L. , Bergstrom, James D.
- 申请人： MERCK & CO. INC.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： MERCK & CO. INC.
- 当前专利权人： MERCK & CO. INC.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Thompson, John Dr.
- 优先权： US698766 19910510; US805602 19911209; US866749 19920415
- 主分类号： C07D493/08
- IPC分类号： C07D493/08 ; C07H19/01 ; A61K31/34 ; A61K31/70
摘要：
Disclosed herein are compounds of structural formula (I)
which are useful as cholesterol lowering agents. These compounds are also useful as inhibitors of squalene synthetase, inhibitors of fungal growth, inhibitors of farnesyl-protein transferase and farnesylation of the oncogene protein Ras. These compounds are also useful in the treatment of cancer.
which are useful as cholesterol lowering agents. These compounds are also useful as inhibitors of squalene synthetase, inhibitors of fungal growth, inhibitors of farnesyl-protein transferase and farnesylation of the oncogene protein Ras. These compounds are also useful in the treatment of cancer.
公开/授权文献
- EP0512865A3 Novel cholesterol lowering compounds 公开/授权日：1992-12-02
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