发明公开
- 专利标题： 4a-Substituted avermectin derivatives
- 专利标题（中）： 4-a-Substantierte Avermectinderivate。
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申请号： EP92305633.7申请日： 1992-06-19
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公开(公告)号： EP0519731A1公开(公告)日： 1992-12-23
- 发明人: Chu, Lin , Jones, Todd K. , Mrozik, Helmut
- 申请人： MERCK & CO. INC.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： MERCK & CO. INC.
- 当前专利权人： MERCK & CO. INC.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Thompson, John Dr.
- 优先权： US717953 19910620; US810999 19911220; US882809 19920519
- 主分类号： C07H17/08
- IPC分类号： C07H17/08 ; C07D493/22 ; A61K31/70 ; A61K31/365 ; A01N43/90
摘要：
Avermectin compounds are substituted at the 4a-position: the 4a-methyl group is first derivatized with a hydroxy group which is then substituted with a variety of alkyl, alkoxy alkyl, or polyalkoxy alkyl groups and derivatives thereof. The compounds are potent antiparasitic and anthelmintic agents and compositions for such uses are also disclosed.
公开/授权文献
- EP0519731B1 4a-Substituted avermectin derivatives 公开/授权日：1998-01-28
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