发明公开
EP0529636A1 Novel isatinoxime derivatives, their preparation and use
失效
Isatinoximderivate，ihre Herstellung und Anwendung。
- 专利标题： Novel isatinoxime derivatives, their preparation and use
- 专利标题（中）： Isatinoximderivate，ihre Herstellung und Anwendung。
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申请号： EP92114654.4申请日： 1992-08-27
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公开(公告)号： EP0529636A1公开(公告)日： 1993-03-03
- 发明人: Wätjen, Frank , Dahl, Bjarne Hugo , Drejer, Jorgen , Jensen, Leif Helth
- 申请人： NEUROSEARCH A/S
- 申请人地址： Smedeland 26 DK-2600 Glostrup DK
- 专利权人： NEUROSEARCH A/S
- 当前专利权人： NEUROSEARCH A/S
- 当前专利权人地址： Smedeland 26 DK-2600 Glostrup DK
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： US751165 19910828; US831851 19920205
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D471/04 ; C07D491/048 ; C07D495/04 ; A61K31/40 ; A61K31/435 ; A61K31/55
摘要：
A compound having the formula
wherein
R⁴ and R⁵ independently are hydrogen, halogen, CF₃, CN, NO₂ or SO₂NR¹R² wherein
R¹ is hydrogen or straight, C₁₋₆-alkyl which may be branched or cyclic,
R² is hydrogen or straight, C₁₋₆-alkyl which may be branched or cyclic,
or wherein R¹ and R² together represent -(CH₂) n -A-(CH₂) m -,
wherein A is O, S, CH₂ or NR I , wherein R I is H, C₁₋₆-alkyl which may be straight, branched or cyclic, n is 0, 1, 2, 3, 4, 5 and m is 0, 1, 2, 3, 4, 5;
Q is NOH, O;
Z = O, S, N-R II ,
wherein R II , R III , R IV and R V independently are hydrogen, benzyl, C₁₋₆-acyl, C₁₋₆-alkoxy which may be branched or cyclic, or C₁₋₆-alkyl which may be branched or cyclic;
X is -(CH₂) o - wherein o is 0, 1, 2, or 3;
Y is -(CH₂) p - wherein p is 0, 1, 2 or 3;
α and β indicate attachment points,
and a method of treating disorders of a mammal, including a human, responsive to the blockade of glutamic and aspartic acid receptors, with the same.
wherein
R⁴ and R⁵ independently are hydrogen, halogen, CF₃, CN, NO₂ or SO₂NR¹R² wherein
R¹ is hydrogen or straight, C₁₋₆-alkyl which may be branched or cyclic,
R² is hydrogen or straight, C₁₋₆-alkyl which may be branched or cyclic,
or wherein R¹ and R² together represent -(CH₂) n -A-(CH₂) m -,
wherein A is O, S, CH₂ or NR I , wherein R I is H, C₁₋₆-alkyl which may be straight, branched or cyclic, n is 0, 1, 2, 3, 4, 5 and m is 0, 1, 2, 3, 4, 5;
Q is NOH, O;
Z = O, S, N-R II ,
wherein R II , R III , R IV and R V independently are hydrogen, benzyl, C₁₋₆-acyl, C₁₋₆-alkoxy which may be branched or cyclic, or C₁₋₆-alkyl which may be branched or cyclic;
X is -(CH₂) o - wherein o is 0, 1, 2, or 3;
Y is -(CH₂) p - wherein p is 0, 1, 2 or 3;
α and β indicate attachment points,
and a method of treating disorders of a mammal, including a human, responsive to the blockade of glutamic and aspartic acid receptors, with the same.
公开/授权文献
- EP0529636B1 Novel isatinoxime derivatives, their preparation and use 公开/授权日：1999-06-23
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