发明公开
EP0546358A2 Pharmaceutical compositions with angiotensin-II-antagonistic activity
失效
Arzneimittel mit血管紧张素II拮抗剂Wirkung。
- 专利标题: Pharmaceutical compositions with angiotensin-II-antagonistic activity
- 专利标题(中): Arzneimittel mit血管紧张素II拮抗剂Wirkung。
-
申请号: EP92119705.9申请日: 1992-11-19
-
公开(公告)号: EP0546358A2公开(公告)日: 1993-06-16
- 发明人: Makino, Tadashi, , Mizukami, Yoshio , Kikuta, Jun-ichi
- 申请人: TAKEDA CHEMICAL INDUSTRIES, LTD.
- 申请人地址: 1-1, Doshomachi 4-chome Chuo-ku, Osaka 541 JP
- 专利权人: TAKEDA CHEMICAL INDUSTRIES, LTD.
- 当前专利权人: TAKEDA CHEMICAL INDUSTRIES, LTD.
- 当前专利权人地址: 1-1, Doshomachi 4-chome Chuo-ku, Osaka 541 JP
- 代理机构: Lederer, Franz, Dr.
- 优先权: JP304924/91 19911120
- 主分类号: A61K31/415
- IPC分类号: A61K31/415 ; A61K31/41 ; A61K31/435 ; A61K31/495 ; A61K31/53
摘要:
A pharmaceutical composition for oral use comprising an effective amount of a compound of the formula (I) having antagonistic action to angiotensin II
(wherein the ring W is an optionally substituted N-containing heterocyclic residue; R 3 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; and n is an integer of 1 or 2) and an oleaginous substance having a lower melting point, and a method for preparing a pharmaceutical composition for oral use comprising an effective amount of a compound of the formula (I) and an oily substance having a lower melting point, which comprises admixing the compound of the formula (I) with an oily substance having a lower melting point and then subjecting the mixture to molding.
(wherein the ring W is an optionally substituted N-containing heterocyclic residue; R 3 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; and n is an integer of 1 or 2) and an oleaginous substance having a lower melting point, and a method for preparing a pharmaceutical composition for oral use comprising an effective amount of a compound of the formula (I) and an oily substance having a lower melting point, which comprises admixing the compound of the formula (I) with an oily substance having a lower melting point and then subjecting the mixture to molding.
公开/授权文献
信息查询