发明公开
EP0557016A1 Naphthalene derivatives, processes for preparing the same, and synthetic intermediates therefor
失效
Naphthalinderivate，ihre Herstellungsverfahren und synthetische Zwischenproduktedafür。
- 专利标题： Naphthalene derivatives, processes for preparing the same, and synthetic intermediates therefor
- 专利标题（中）： Naphthalinderivate，ihre Herstellungsverfahren und synthetische Zwischenproduktedafür。
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申请号： EP93300998.7申请日： 1993-02-11
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公开(公告)号： EP0557016A1公开(公告)日： 1993-08-25
- 发明人: Iwasaki, Tameo , Kondo, Kazuhiko , Ikezawa, Katsuo , Kikkawa, Hideo , Yamagata, Shinsuke
- 申请人： TANABE SEIYAKU CO., LTD.
- 申请人地址： 2-10, Dosho-machi 3-chome Chuo-ku Osaka JP
- 专利权人： TANABE SEIYAKU CO., LTD.
- 当前专利权人： TANABE SEIYAKU CO., LTD.
- 当前专利权人地址： 2-10, Dosho-machi 3-chome Chuo-ku Osaka JP
- 代理机构： Hardisty, David Robert
- 优先权： JP85118/92 19920220
- 主分类号： C07D213/30
- IPC分类号： C07D213/30 ; C07D213/64 ; C07D237/14 ; C07D405/04 ; A61K31/44 ; A61K31/50
摘要：
Naphthalene derivative of the formula [I]:
wherein R¹ and R² are the same or different and are hydrogen atom, hydroxy group, cyclo-lower alkyloxy group, substituted or unsubstituted lower alkoxy group, or both combine each other to form lower alkylenedioxy group, R³ is substituted or unsubstituted nitrogen-containing 6-membered heterocyclic group, and groups of the formulae: -OR⁴ and -OR⁵ are the same or different and are protected or unprotected hydroxy group, processes for preparing thereof, and synthetic intermediates therefor, these compounds have excellent bronchodilating activity, and are useful in the prophylaxis and treatment of asthma.
wherein R¹ and R² are the same or different and are hydrogen atom, hydroxy group, cyclo-lower alkyloxy group, substituted or unsubstituted lower alkoxy group, or both combine each other to form lower alkylenedioxy group, R³ is substituted or unsubstituted nitrogen-containing 6-membered heterocyclic group, and groups of the formulae: -OR⁴ and -OR⁵ are the same or different and are protected or unprotected hydroxy group, processes for preparing thereof, and synthetic intermediates therefor, these compounds have excellent bronchodilating activity, and are useful in the prophylaxis and treatment of asthma.
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