发明公开
- 专利标题： Substituted benzoate derivatives
- 专利标题（中）： 取代苯甲酸衍生物。
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申请号： EP93305630.1申请日： 1993-07-19
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公开(公告)号： EP0580378A1公开(公告)日： 1994-01-26
- 发明人: Matsutani, Shigeru , Yoshida, Tadashi , Sakazaki, Ryuji , Fujii, Yasuhiko , Tanaka, Kazushige
- 申请人： SHIONOGI & CO., LTD.
- 申请人地址： 1-8, Doshomachi 3-chome, Chuo-ku Osaka 541 JP
- 专利权人： SHIONOGI & CO., LTD.
- 当前专利权人： SHIONOGI & CO., LTD.
- 当前专利权人地址： 1-8, Doshomachi 3-chome, Chuo-ku Osaka 541 JP
- 代理机构： Hardisty, David Robert
- 优先权： JP196789/92 19920723
- 主分类号： C07C69/92
- IPC分类号： C07C69/92 ; C07C229/38 ; C07C271/20 ; A61K31/235
摘要：
The present invention relates to the compounds of the formula:
in which R¹, R², R³, R⁴, R⁵, R⁶, R⁷, and R⁸ are independently hydrogen, lower alkyl which is optionally substituted, lower alkoxy which is optionally substituted, hydroxy, acyloxy, or halogen; R⁹ is hydrogen, hydroxy, acyloxy, lower alkyl which is optionally substituted, lower alkoxy which is optionally substituted, or lower alkylamino which is optionally substituted; E¹ is hydrogen, or an ester residue; m is an integer of from 1 to 4;
or a pharmaceutically acceptable salt thereof. The compounds of the present invention exhibit phospholipase A₂ inhibitory activity, and can be used in treating inflammatory conditions.
in which R¹, R², R³, R⁴, R⁵, R⁶, R⁷, and R⁸ are independently hydrogen, lower alkyl which is optionally substituted, lower alkoxy which is optionally substituted, hydroxy, acyloxy, or halogen; R⁹ is hydrogen, hydroxy, acyloxy, lower alkyl which is optionally substituted, lower alkoxy which is optionally substituted, or lower alkylamino which is optionally substituted; E¹ is hydrogen, or an ester residue; m is an integer of from 1 to 4;
or a pharmaceutically acceptable salt thereof. The compounds of the present invention exhibit phospholipase A₂ inhibitory activity, and can be used in treating inflammatory conditions.
公开/授权文献
- EP0580378B1 Substituted benzoate derivatives 公开/授权日：1996-06-26
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