发明授权
EP0586607B1 HEREGULINS (HRGs), BINDING PROTEINS OF P185?erb2
失效
HEREGULINE（HRGS），P185？ERB2约束力Proteine
- 专利标题： HEREGULINS (HRGs), BINDING PROTEINS OF P185?erb2
- 专利标题（中）： HEREGULINE（HRGS），P185？ERB2约束力Proteine
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申请号： EP92915976.2申请日： 1992-05-21
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公开(公告)号： EP0586607B1公开(公告)日： 2003-07-23
- 发明人: VANDLEN, Richard, L. , HOLMES, William, E.
- 申请人： GENENTECH, INC.
- 申请人地址： 1 DNA Way South San Francisco California 94080 US
- 专利权人： GENENTECH, INC.
- 当前专利权人： GENENTECH, INC.
- 当前专利权人地址： 1 DNA Way South San Francisco California 94080 US
- 代理机构： Armitage, Ian Michael
- 优先权： US705256 19910524; US765212 19910925; US790801 19911108; US847743 19920306; US880917 19920511
- 国际公布： WO92020798 19921126
- 主分类号： C07K14/475
- IPC分类号： C07K14/475 ; C12P21/02 ; C12N5/10
摘要：
A novel polypeptide with binding affinity for the p185 receptor, designated heregulin- alpha , has been identified and purified from cultured human cells. DNA sequences encoding additional heregulin polypeptides, designated heregulin- alpha , heregulin- beta 1, heregulin- beta 2, heregulin- beta 2-like, and heregulin- beta 3, have been isolated, sequenced and expressed. Provided herein are nucleic acid sequences encoding the amino acid sequences of heregulins useful in the production of heregulins by recombinant means. Further provided are the amino acid sequences of heregulins and purification methods therefor. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.
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