发明公开
- 专利标题： Tricyclic compounds and pharmaceutical compositions containing them
- 专利标题（中）： 三环化合物和含有它们的药物组合物
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申请号： EP93307261.3申请日： 1993-09-15
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公开(公告)号： EP0588608A3公开(公告)日： 1994-04-20
- 发明人: Yanase, Masashi , Kumazawa, Toshiaki , Shirakura, Shiro , Oishi, Eiko , Yamada, Koji
- 申请人： KYOWA HAKKO KOGYO CO., LTD.
- 申请人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo-to JP
- 专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo-to JP
- 代理机构： Lambert, Hugh Richmond
- 优先权： JP246845/92 19920916
- 主分类号： C07D313/12
- IPC分类号： C07D313/12 ; A61K31/335
摘要：
[Purpose] To provide a tricyclic compound having an ACAT inhibiting activity, which are useful for treatment of hyperlipemia and arteriosclerosis. [Constitution] A tricyclic compound represented by formula (I) :
where X¹-X² represents CH=CH-CH=CH, CH=CH-CH=N or S-CH=CH;
Y-Z represents CH₂-O, CH=CH or CH₂-CH₂
L-M represents C=CR⁹ or CH-CR¹⁰R¹¹; W represents NR⁴ or O;
R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ independently represents hydrogen or lower alkyl.
where X¹-X² represents CH=CH-CH=CH, CH=CH-CH=N or S-CH=CH;
Y-Z represents CH₂-O, CH=CH or CH₂-CH₂
L-M represents C=CR⁹ or CH-CR¹⁰R¹¹; W represents NR⁴ or O;
R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ independently represents hydrogen or lower alkyl.
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