发明公开
- 专利标题： ENDOTHELIN-ANTAGONIZING PEPTIDE
- 专利标题（中）： 肽肽ALS ANTAGONISTEN DES ENDOTHELIN。
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申请号： EP93900411.5申请日： 1992-12-28
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公开(公告)号： EP0603399A1公开(公告)日： 1994-06-29
- 发明人: TANAKA, Takeo , MORISHITA, Yoshikazu , NOZAWA, Mika , CHIBA, Shigeru , KAWAMOTO, Isao , TSUKUDA, Eiji , YOSHIDA, Mayumi , SHIMAZAKI, Chieko , YAMAGUCHI, Kazuo , MATSUDA, Yuzuru , KITAMURA, Shigeto , IKEMURA, Toshihide , OGAWA, Tatsuhiro , YANO, Keiichi , SUZAWA, Toshiyuki , SHIBATA, Kenji , YAMASAKI, Motoo
- 申请人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA
- 申请人地址： 6-1, Ohte-machi 1-chome Chiyoda-ku, Tokyo 100 JP
- 专利权人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA
- 当前专利权人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA
- 当前专利权人地址： 6-1, Ohte-machi 1-chome Chiyoda-ku, Tokyo 100 JP
- 代理机构： VOSSIUS & PARTNER
- 优先权： JP347293/91 19911227
- 国际公布： WO9313218 19930708
- 主分类号： C12P21/00
- IPC分类号： C12P21/00
摘要：
A novel peptide represented by the following general formula and a process for producing the same: X-A-Trp-B-Gly-Thr-E-G-Y wherein, A represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X¹-Gly or X³-Cys-X²; and Y represents hydroxy, lower alkoxy, amino, Y¹-Asp-Z or Y²-Cys-Z. The peptide is isolated from the product of culture of a streptomyces and has an endothelin antagonism and an activity of suppressing the rise of an intracellular calcium or cyclic guanosine-3,5-phosphate concentration caused by endothelin.
公开/授权文献
- EP0603399B1 ENDOTHELIN-ANTAGONIZING PEPTIDE 公开/授权日：2002-09-11
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