发明公开
EP0604353A1 Benzimidazole compounds, their preparation and use
失效
Benzimidazolderivate，Verfahren zu deren Herstellung und Anwendung。
- 专利标题： Benzimidazole compounds, their preparation and use
- 专利标题（中）： Benzimidazolderivate，Verfahren zu deren Herstellung und Anwendung。
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申请号： EP93610064.3申请日： 1993-12-20
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公开(公告)号： EP0604353A1公开(公告)日： 1994-06-29
- 发明人: Axelsson, Oskar , Peters, Dan , Nielsen, Elsebet Ostergaard
- 申请人： NEUROSEARCH A/S
- 申请人地址： Smedeland 26B DK-2600 Glostrup DK
- 专利权人： NEUROSEARCH A/S
- 当前专利权人： NEUROSEARCH A/S
- 当前专利权人地址： Smedeland 26B DK-2600 Glostrup DK
- 代理机构： Wulff, Peter Samuel
- 优先权： DK1540/92 19921223
- 主分类号： C07D417/10
- IPC分类号： C07D417/10 ; C07D235/30 ; C07D409/10 ; C07D401/10 ; C07D405/10 ; C07D403/10 ; A61K31/41 ; A61K31/425 ; A61K31/44
摘要：
The present invention discloses compounds of the formula
or a pharmaceutically-acceptable addition salt thereof
wherein
R' and R'' independently of each other are hydrogen or alkyl, or R' and R'' together form a 3 to 6 membered alkylene chain;
one of R¹ and R² is aryl which may be substituted one or more times with halogen, CF₃, CN, OH, alkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, amino, nitro, sulphamoyl, tetrazolyl, CO₂H, CO₂-alkyl and the other of R¹ and R² is hydrogen, halogen, alkoxy, amino or alkyl; and
R⁴, R⁵, R⁶ and R⁷ independently of each other are hydrogen, halogen, amino, nitro, CN, OH, CF₃, alkyl or alkoxy; and n is 0 or 1; provided that neither of R¹ and R² is phenyl or substituted phenyl when n is 0.
The compounds are useful as pharmaceuticals, for example, in the treatment of ischemia, anoxia, migraine and psychosis.
or a pharmaceutically-acceptable addition salt thereof
wherein
R' and R'' independently of each other are hydrogen or alkyl, or R' and R'' together form a 3 to 6 membered alkylene chain;
one of R¹ and R² is aryl which may be substituted one or more times with halogen, CF₃, CN, OH, alkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, amino, nitro, sulphamoyl, tetrazolyl, CO₂H, CO₂-alkyl and the other of R¹ and R² is hydrogen, halogen, alkoxy, amino or alkyl; and
R⁴, R⁵, R⁶ and R⁷ independently of each other are hydrogen, halogen, amino, nitro, CN, OH, CF₃, alkyl or alkoxy; and n is 0 or 1; provided that neither of R¹ and R² is phenyl or substituted phenyl when n is 0.
The compounds are useful as pharmaceuticals, for example, in the treatment of ischemia, anoxia, migraine and psychosis.
公开/授权文献
- EP0604353B1 Benzimidazole compounds, their preparation and use 公开/授权日：1998-07-01
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