发明公开
EP0628569A1 Triterpene derivatives and endothelin-receptor antagonists containing the same
失效
Triterpenderivate und diese enthaltende内皮素受体拮抗剂。
- 专利标题： Triterpene derivatives and endothelin-receptor antagonists containing the same
- 专利标题（中）： Triterpenderivate und diese enthaltende内皮素受体拮抗剂。
-
申请号： EP94304165.7申请日： 1994-06-09
-
公开(公告)号： EP0628569A1公开(公告)日： 1994-12-14
- 发明人: Konoike, Toshiro , Araki, Yoshitaka , Hayashi, Tetsuyoshi , Sakurai, Kensuke , Tozyo, Takehiko, 11-501-2304
- 申请人： SHIONOGI & CO., LTD.
- 申请人地址： 1-8, Doshomachi 3-chome, Chuo-ku Osaka 541 JP
- 专利权人： SHIONOGI & CO., LTD.
- 当前专利权人： SHIONOGI & CO., LTD.
- 当前专利权人地址： 1-8, Doshomachi 3-chome, Chuo-ku Osaka 541 JP
- 代理机构： Baverstock, Michael George Douglas
- 优先权： JP140416/93 19930611
- 主分类号： C07J63/00
- IPC分类号： C07J63/00 ; A61K31/705 ; A61K35/78
摘要：
Triterpene derivatives of the formula (I):
wherein R¹ is hydrogen or metabolic ester residue; and R² is hydrogen or -R³-R⁴ wherein R³ is -SO₃-, -CH₂COO-, -COCOO-, or -COR⁵COO- (R⁵ is lower alkylene or lower alkenylene), and R⁴ is hydrogen or metabolic ester residue, or
pharmaceutically acceptable salts thereof, have anti-endothelin activities and are useful in prophylaxis and treatment of diseases caused by excessive secretion of endothelin.
wherein R¹ is hydrogen or metabolic ester residue; and R² is hydrogen or -R³-R⁴ wherein R³ is -SO₃-, -CH₂COO-, -COCOO-, or -COR⁵COO- (R⁵ is lower alkylene or lower alkenylene), and R⁴ is hydrogen or metabolic ester residue, or
pharmaceutically acceptable salts thereof, have anti-endothelin activities and are useful in prophylaxis and treatment of diseases caused by excessive secretion of endothelin.
公开/授权文献
信息查询
