发明授权
EP0629197B1 1-ALKOXY-(2-ALKOXY- OR CYCLOALKOXY)-4-(CYCLO THIOALKYL- OR CYCLOTHIOALKENYL)BENZENES AS INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASE AND TUMOUR NECROSIS FACTOR
失效
1-烷氧基-2-（烷氧基或环烷氧基）-4-（CYCLOTHIOALKYL- OR cyclothioalkenyl）苯环状AMP磷酸二酯酶抑制剂和肿瘤坏死因子
- 专利标题： 1-ALKOXY-(2-ALKOXY- OR CYCLOALKOXY)-4-(CYCLO THIOALKYL- OR CYCLOTHIOALKENYL)BENZENES AS INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASE AND TUMOUR NECROSIS FACTOR
- 专利标题（中）： 1-烷氧基-2-（烷氧基或环烷氧基）-4-（CYCLOTHIOALKYL- OR cyclothioalkenyl）苯环状AMP磷酸二酯酶抑制剂和肿瘤坏死因子
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申请号： EP93905503.4申请日： 1993-03-04
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公开(公告)号： EP0629197B1公开(公告)日： 1997-08-20
- 发明人: FENTON, Garry , MASON, Jonathan, Stephen , PALFREYMAN, Malcolm, Norman , RATCLIFFE, Andrew, James
- 申请人： RHONE-POULENC RORER LIMITED
- 申请人地址： RPR House, 50 Kings Hill Avenue, Kings Hill West Malling, Kent ME19 4TA GB
- 专利权人： RHONE-POULENC RORER LIMITED
- 当前专利权人： RHONE-POULENC RORER LIMITED
- 当前专利权人地址： RPR House, 50 Kings Hill Avenue, Kings Hill West Malling, Kent ME19 4TA GB
- 代理机构： Caffin, Lee
- 优先权： GB9204808 19920304
- 国际公布： WO9318024 19930916
- 主分类号： C07D335/02
- IPC分类号： C07D335/02 ; C07D333/16 ; C07D333/32 ; C07D333/48 ; A61K31/38
摘要：
This invention is directed to 1-alkoxy-2-(alkoxy- or cycloalkyloxy-)-4-(cyclothioalkyl- or cyclothioalkenyl-)benzene compounds that inhibit cyclic AMP phosphodiesterase or tumor necrosis factor (TNF) and are useful in treating patients suffering from disease state capable of being modulated by inhibiting production of cyclic AMP phosphodiesterase or TNF by administering the compound to the patient. The invention is also directed to the preparation of these compounds, pharmaceutical compositions containing these compounds and methods for their pharmaceutical use.
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