发明公开
EP0642509A1 NOVEL POTENT INDUCERS OF TERMINAL DIFFERENTIATION AND METHODS OF USE THEREOF
失效
终末分化和新的高效电感器的使用方法。
- 专利标题: NOVEL POTENT INDUCERS OF TERMINAL DIFFERENTIATION AND METHODS OF USE THEREOF
- 专利标题(中): 终末分化和新的高效电感器的使用方法。
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申请号: EP92922033.0申请日: 1992-10-05
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公开(公告)号: EP0642509A1公开(公告)日: 1995-03-15
- 发明人: BRESLOW, Ronald , MARKS, Paul, A. , RIFKIND, Richard, A. , JURSIC, Branko
- 申请人: Sloan-Kettering Institute For Cancer Research , The Trustees of Columbia University in the City of New York
- 申请人地址: 1275 York Avenue New York, New York 10021 US
- 专利权人: Sloan-Kettering Institute For Cancer Research,The Trustees of Columbia University in the City of New York
- 当前专利权人: Sloan-Kettering Institute For Cancer Research,The Trustees of Columbia University in the City of New York
- 当前专利权人地址: 1275 York Avenue New York, New York 10021 US
- 代理机构: VOSSIUS & PARTNER
- 优先权: US19910771760 19911004
- 国际公布: WO1993007148 19930415
- 主分类号: C07D295
- IPC分类号: C07D295 ; A61K31 ; A61P35 ; A61P43 ; C07C229 ; C07C233 ; C07C237 ; C07C255 ; C07C259 ; C07C271 ; C07C275 ; C07D211 ; C07D213 ; C07D277 ; C07D487 ; C07D519
摘要:
The present invention provides the compound having structure (I), wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R1 and R2 are different, R1 = R3-N-R4, wherein each of R3 and R4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R3 and R4 bond together to form a piperidine group and R2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8. The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present inventtion provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.
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