发明公开
- 专利标题： AMINO ACID DERIVATIVE AND USE THEREOF.
- 专利标题（中）： 氨基衍生物UNE用途。
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申请号： EP93910424申请日： 1993-06-01
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公开(公告)号： EP0644181A4公开(公告)日： 1995-07-05
- 发明人: NISHIKAWA NAOYUKI , ORIKASA ATSUSHI , KOMAZAWA HIROYUKI , KOJIMA MASAYOSHI , SAIKI IKUO-NISHI-CHOME , AZUMA ICHIRO
- 申请人： FUJI PHOTO FILM CO LTD
- 专利权人： FUJI PHOTO FILM CO LTD
- 当前专利权人： FUJI PHOTO FILM CO LTD
- 优先权： JP14260792 1992-06-03; JP11984893 1993-05-21
- 主分类号： A61K31/195
- IPC分类号： A61K31/195 ; A61K31/22 ; A61K38/00 ; A61P35/00 ; A61P43/00 ; C07C233/47 ; C07C237/12 ; C07C279/14 ; C07C279/20 ; C07D251/52 ; C07K5/02 ; C07K5/06 ; C07K5/072 ; C07C237/22
摘要：
An amino acid derivative represented by general formula (I), a pharmacologically acceptable salt thereof, and a cancer metastasis inhibitor containing the same, wherein L?1 and L2¿ represent each an amino acid residue, etc.; A?1 and A3¿ represent each C=O; A2 represents alkylene, etc.; m and n represent each an integer of 1 to 5; V represents -NHC(=NH)NH¿2?, etc.; W represents -COOH, etc.; R?1 and R2¿ represent each hydrogen, alkyl, etc.; R?3 and R4¿ represent each hydrogen, etc.; and X and Y represent each -NH- or -O-. The derivative has a potent effect of inhibiting cancer metastasis and is reduced in the activity of inhibiting platelet agglutination and the anticoagulant activity.
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