发明公开
EP0644937A1 THERAPEUTIC AND DIAGNOSTIC METHODS BASED ON NEUROTROPHIN-4 EXPRESSION
失效
基于神经营养-4的表达治疗和诊断方法。
- 专利标题： THERAPEUTIC AND DIAGNOSTIC METHODS BASED ON NEUROTROPHIN-4 EXPRESSION
- 专利标题（中）： 基于神经营养-4的表达治疗和诊断方法。
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申请号： EP93915340.0申请日： 1993-06-11
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公开(公告)号： EP0644937A1公开(公告)日： 1995-03-29
- 发明人: IP, Nancy , ALTAR, Charles, A. , DISTEFANO, Peter , VENTIMIGLIA, Roseann , WIEGAND, Stanley , WONG, Vivien , YANCOPOULOS, George, D.
- 申请人： REGENERON PHARMACEUTICALS, INC.
- 申请人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591-6707 US
- 专利权人： REGENERON PHARMACEUTICALS, INC.
- 当前专利权人： REGENERON PHARMACEUTICALS, INC.
- 当前专利权人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591-6707 US
- 代理机构： Durand, Yves Armand Louis
- 优先权： US19920898194 19920612
- 国际公布： WO1993025684 19931223
- 主分类号： C12N15
- IPC分类号： C12N15 ; A61K38 ; A61P25 ; C07K14 ; C12P21 ; C12R1
摘要：
The present invention relates to neurotrophin-4 (NT-4), a newly characterized member of the BDNF/NGF/NT-3 gene family. The present invention provides for nucleic acid molecules encoding NT-4. Such molecules may comprise a sequence substantially as set forth for NT-4 in the figure [SEQ ID NO:1 (NT-4, viper)]. The present invention provides for therapeutic and diagnostic methods based on human NT-4 expression, specifically the potential to treat motor neuron diseases and prostate localized diseases, immunological related neuromuscular disorders, and peripheral and central nervous system disorders including Alzheimer's disease, Parkinson's disease and Huntington's chorea and epilepsy.
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