发明公开
EP0652879A1 1-AZAADAMANTANE DERIVATIVES AS 5-HT AGONISTS OR ANTAGONISTS
失效
1-AZAADAMANTANDERIVATE ALS 5-HT 4激动剂或拮抗剂和/或5-HT3拮抗剂。
- 专利标题: 1-AZAADAMANTANE DERIVATIVES AS 5-HT AGONISTS OR ANTAGONISTS
- 专利标题(中): 1-AZAADAMANTANDERIVATE ALS 5-HT 4激动剂或拮抗剂和/或5-HT3拮抗剂。
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申请号: EP93916671.0申请日: 1993-06-25
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公开(公告)号: EP0652879A1公开(公告)日: 1995-05-17
- 发明人: FLYNN, Daniel, Lee , SHONE, Robert, L.
- 申请人: G.D. SEARLE & CO.
- 申请人地址: P.O. Box 5110 Chicago IL 60680-5110 US
- 专利权人: G.D. SEARLE & CO.
- 当前专利权人: G.D. SEARLE & CO.
- 当前专利权人地址: P.O. Box 5110 Chicago IL 60680-5110 US
- 代理机构: Beil, Hans Chr., Dr.
- 优先权: US19920919679 19920727
- 国际公布: WO1994002482 19940203
- 主分类号: A61K31
- IPC分类号: A61K31 ; A61P1 ; A61P25 ; A61P43 ; C07D471
摘要:
This invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein Z is selected from the group consisting of (a) and (b), R1 is alkoxy of one to six carbon atoms; R2, R3, R4 and R5 are the same or different and are selected from the group consisting of hydrogen, halogen, CF3, hydroxy, alkoxy of one to six carbon atoms, acyl of two to seven carbon atoms, amino, amino substituted by one or two alkyl groups of one to six carbon atoms, C2-C7 acylamino, aminocarbonyl, aminosulfone optionally substituted by one or two alkyl groups of one to six carbon atoms, C1-C6 alkylsulfone and nitro; m is 1 or 2; X is 0 or NR7; and R7 is hydrogen or alkyl of 1 to 6 carbon atoms.
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