发明公开
- 专利标题： CLONING AND EXPRESSION OF A PROTEIN ANTIGEN OF TOXOPLASMA GONDII
- 专利标题（中）： 克隆和弓形虫蛋白抗原的表达。
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申请号： EP92901011.0申请日： 1991-12-16
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公开(公告)号： EP0652956A1公开(公告)日： 1995-05-17
- 发明人: SAAVEDRA-DURAN, Rafael , HERION, Pascal
- 申请人： SMITHKLINE BEECHAM BIOLOGICALS s.a. , N.V. INNOGENETICS S.A.
- 申请人地址： 89 rue de l'Institut B-1330 Rixensart BE
- 专利权人： SMITHKLINE BEECHAM BIOLOGICALS s.a.,N.V. INNOGENETICS S.A.
- 当前专利权人： SMITHKLINE BEECHAM BIOLOGICALS s.a.,N.V. INNOGENETICS S.A.
- 当前专利权人地址： 89 rue de l'Institut B-1330 Rixensart BE
- 代理机构： Tyrrell, Arthur William Russell, Dr., et al
- 优先权： GB19900027728 19901220
- 国际公布： WO1992011366 19920709
- 主分类号： A61K39
- IPC分类号： A61K39 ; A61P31 ; C07K14 ; C07K16 ; C12N1 ; C12N15 ; C12P21 ; G01N33 ; C12R1
摘要：
A purified antigen of T. gondii having a molecular weight of 54-kDa (as determined by Western blotting) is provided which is reactive with antibodies raised against a recombinant protein obtained by expression of a defined T. gondii cDNA (Figure 2) in a host cell; also provided are immunogenic fragments of the 54-kDa antigen. Recombinant DNA encoding the 54-kDa antigen, host cells for expression of such DNA, a vaccine for treating or preventing toxoplasmosis infection in humans and animals, and test kits for detection of T. gondii antigen or antibody are also described.
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