发明公开
- 专利标题： METHOD FOR PREPARING A METAL-RADIONUCLIDE-LABELLED PROTEIN
- 专利标题（中）： 的金属放射性核素标记的蛋白质的制造方法。
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申请号： EP94915454.0申请日： 1994-05-02
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公开(公告)号： EP0654043A1公开(公告)日： 1995-05-24
- 发明人: VERBRUGGEN, Alfons, M.
- 申请人： MALLINCKRODT MEDICAL, INC.
- 申请人地址： 675 McDonnell Blvd, P.O. Box 5840 St. Louis, MO 63134 US
- 专利权人： MALLINCKRODT MEDICAL, INC.
- 当前专利权人： MALLINCKRODT MEDICAL, INC.
- 当前专利权人地址： 675 McDonnell Blvd, P.O. Box 5840 St. Louis, MO 63134 US
- 代理机构： Jones, Alan John
- 优先权： EP19930201249 19930503
- 国际公布： WO1994025488 19941110
- 主分类号： A61K39
- IPC分类号： A61K39 ; A61K51
摘要：
The invention relates to a method of preparing a metal-radionuclide-labelled protein or proteinaceous material, which is intended for diagnostic or therapeutic application, by reacting a protein or a proteinaceous material with a bifunctional agent for coupling the radionuclide to the protein or proteinaceous material, a protein conjugate being formed by reaction between bifunctional agent and free amino groups or mercapto groups in the protein or proteinaceous material, and then complexing the radionuclide with the conjugate thus formed to a radionuclide complex. The invention further relates to the labelled protein or proteinaceous material thus obtained, and to a kit for preparing a radiopharmaceutical composition, which kit comprises the above-mentioned polyfunctional agent or a protein conjugate formed by reaction of a protein or proteinaceous material with said polyfunctional agent.
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