发明公开
EP0659216A1 VECTEUR RETROVIRAL POUR LE TRANSFERT ET L'EXPRESSION DE GENES A VISEE THERAPEUTIQUE, DANS DES CELLULES EUCARYOTES 失效
病毒载体RETRO FOR IN EUKARYOTEZELLEN转移与表达治疗基因。

  • 专利标题: VECTEUR RETROVIRAL POUR LE TRANSFERT ET L'EXPRESSION DE GENES A VISEE THERAPEUTIQUE, DANS DES CELLULES EUCARYOTES
  • 专利标题(英): Retroviral vector for the transfer and expression of genes for therapeutical purposes in eucaryotic cells
  • 专利标题(中): 病毒载体RETRO FOR IN EUKARYOTEZELLEN转移与表达治疗基因。
  • 申请号: EP94921008.0
    申请日: 1994-06-30
  • 公开(公告)号: EP0659216A1
    公开(公告)日: 1995-06-28
  • 发明人: Cohen-Haguenauer, Odile
  • 申请人: Cohen-Haguenauer, Odile
  • 申请人地址: 35, rue Cortambert F-75116 Paris FR
  • 专利权人: Cohen-Haguenauer, Odile
  • 当前专利权人: Cohen-Haguenauer, Odile
  • 当前专利权人地址: 35, rue Cortambert F-75116 Paris FR
  • 代理机构: Desaix, Anne, et al
  • 优先权: FR19930008015 19930630
  • 国际公布: WO1995001447 19950112
  • 主分类号: C12N15
  • IPC分类号: C12N15 A61K31 A61K48 C07H21 C12N5
VECTEUR RETROVIRAL POUR LE TRANSFERT ET L'EXPRESSION DE GENES A VISEE THERAPEUTIQUE, DANS DES CELLULES EUCARYOTES
摘要:
The invention relates to a recombinant vector for the cloning and/or expression and/or transfer of an exogenous nucleotide sequence, said vector being characterized in that it comprises any sequence contained in the fragment C-laI-PvuII comprising the nucleotides 7702 and 1527 of the sequence given in figure (1) and comprising the chain LTR comprised between the nucleotides 7842 and 144, the site PBS starting at the nucleotide 145, the encapsidation sequence comprised in the chain of 250 nucleotides following the end of the LTR sequence, said sequence being capable of controlling the cloning and/or expression and/or tranfer of the exogenous sequence, regardless of its transcriptional orientation with respect to the transcriptional orientation of the virus. The invention also relates to the utilisation of said vector for the transfer and/or cloning and/or expression of genes particularly for a genic therapy.
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