发明授权
EP0662958B1 1-(2-OXO-ACETYL)-PIPERIDINE-2-CARBOXYLIC ACID DERIVATIVES AS MULTI-DRUG-RESISTENT CANCER CELL SENSITIZERS
失效
1-（2-氧代 - 乙酰基） - 哌啶-2-羧酸衍生物作为增感剂对多药耐药性的癌细胞
- 专利标题： 1-(2-OXO-ACETYL)-PIPERIDINE-2-CARBOXYLIC ACID DERIVATIVES AS MULTI-DRUG-RESISTENT CANCER CELL SENSITIZERS
- 专利标题（中）： 1-（2-氧代 - 乙酰基） - 哌啶-2-羧酸衍生物作为增感剂对多药耐药性的癌细胞
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申请号： EP93922748.4申请日： 1993-09-27
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公开(公告)号： EP0662958B1公开(公告)日： 2002-12-11
- 发明人: ARMISTEAD, David, M. , SAUNDERS, Jeffrey, O. , BOGER, Joshua, S.
- 申请人： VERTEX PHARMACEUTICALS INCORPORATED
- 申请人地址： 40 Allston Street Cambridge, MA 02139-4211 US
- 专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人地址： 40 Allston Street Cambridge, MA 02139-4211 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US952299 19920928
- 国际公布： WO94007858 19940414
- 主分类号： C07D211/60
- IPC分类号： C07D211/60 ; C07D401/12 ; C07D487/04 ; A61K31/445
摘要：
The present invention relates to novel compounds of formula (I) which maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance and for use in multi-drug resistant cancer therapy.
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