发明授权
EP0667855B1 SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS
失效
取代芳和杂芳基炔-N-羟基脲衍生物作为抑制剂白三烯生物合成
- 专利标题： SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS
- 专利标题（中）： 取代芳和杂芳基炔-N-羟基脲衍生物作为抑制剂白三烯生物合成
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申请号： EP94902209.9申请日： 1993-11-05
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公开(公告)号： EP0667855B1公开(公告)日： 1999-03-24
- 发明人: BASHA, Anwer , BHATIA, Pramila , BROOKS, Dee, W. , CRAIG, Richard, A. , RATAJCZYK, James, D. , STEWART, Andrew, O.
- 申请人： ABBOTT LABORATORIES
- 申请人地址： One Abbott Park Road Abbott Park, Illinois 60064-3500 US
- 专利权人： ABBOTT LABORATORIES
- 当前专利权人： ABBOTT LABORATORIES
- 当前专利权人地址： One Abbott Park Road Abbott Park, Illinois 60064-3500 US
- 代理机构： Modiano, Guido, Dr.-Ing.
- 优先权： US973100 19921106
- 国际公布： WO9411342 19940526
- 主分类号： C07C275/20
- IPC分类号： C07C275/20 ; A61K31/17 ; C07C275/64 ; C07D307/52
摘要：
The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More particularly, this invention concerns certain substituted arylalkynyl- and ((heteroaryl)alkynyl)-N-hydroxy-ureas which inhibit leukotriene biosynthesis, to pharmaceutical compositions of these compounds and to a method of inhibiting leukotriene biosynthesis.
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