发明公开
EP0672047A1 ANTIALLERGIC IMIDAZO 1,2-a](PYRROLO, THIENO OR FURANO) 2,3-d]AZEPINE DERIVATIVES
失效
（1,2-a）（PYRROLO，THIENO ODER FURANO）（2,3-d）亚氨基四氢呋喃。
- 专利标题： ANTIALLERGIC IMIDAZO 1,2-a](PYRROLO, THIENO OR FURANO) 2,3-d]AZEPINE DERIVATIVES
- 专利标题（中）： （1,2-a）（PYRROLO，THIENO ODER FURANO）（2,3-d）亚氨基四氢呋喃。
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申请号： EP94901887.0申请日： 1993-11-25
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公开(公告)号： EP0672047A1公开(公告)日： 1995-09-20
- 发明人: JANSSENS, Frans, Eduard , DIELS, Gaston, Stanislas, Marcella , LEENAERTS, Joseph, Elisabeth
- 申请人： JANSSEN PHARMACEUTICA N.V.
- 申请人地址： Turnhoutseweg 30 B-2340 Beerse BE
- 专利权人： JANSSEN PHARMACEUTICA N.V.
- 当前专利权人： JANSSEN PHARMACEUTICA N.V.
- 当前专利权人地址： Turnhoutseweg 30 B-2340 Beerse BE
- 代理机构： Wante, Dirk, et al
- 优先权： EP19920203778 19921204
- 国际公布： WO1994013680 19940623
- 主分类号： C07D487
- IPC分类号： C07D487 ; A61K31 ; A61P37 ; C07D491 ; C07D495 ; C07D519
摘要：
Antiallergic imidazo[1,2-a](pyrrolo, thieno or furano)[2,3-d]azepines of formula (I), the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; R1 represents hydrogen, C¿1-4?alkyl, halo, ethenyle substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, hydroxyC1-4alkyl, formyl, hydroxycarbonyl or hydroxycarbonylC1-4alkyl; R?2¿ represents hydrogen, C¿1-4?alkyl, ethenyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, C1-4alkyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, hydroxyC1-4alkyl, formyl or hydroxycarbonyl; R?3¿ represents hydrogen, C¿1-4?alkyl, hydroxyC1-4alkyl, phenyl or halo; X represents O, S or NR?4¿; L represents hydrogen; C¿1-6?alkyl; substituted C1-6alkyl; C3-6alkenyl; C3-6alkenyl substituted with aryl; or a radical of the formula: -Alk-Y-Het?1¿ (a-1), -Alk-NH-CO-Het2 (a-2) or Alk-Het3 (a-3). Compositions comprising said compounds, processes of preparing the same and intermediates in the preparation thereof.
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