发明公开
- 专利标题: A therapeutic agent for thrombocytopenia and indolocarbazole derivatives
- 专利标题(中): 治疗血栓形成和吲哚卡巴唑衍生物。
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申请号: EP95103951.0申请日: 1995-03-17
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公开(公告)号: EP0675125A1公开(公告)日: 1995-10-04
- 发明人: Murakata, Chikara , Kanai, Fumihiko , Saitoh, Yutaka , Shiotsu, Yukimasa , Shiraki, Takako , Tamaoki, Tatsuya , Akinaga, Shiro, 512-1, Minamiisshiki , Okabe, Masami
- 申请人: KYOWA HAKKO KOGYO CO., LTD.
- 申请人地址: 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo 100 JP
- 专利权人: KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人: KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址: 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo 100 JP
- 代理机构: Casalonga, Axel
- 优先权: JP49579/94 19940318
- 主分类号: C07D487/14
- IPC分类号: C07D487/14 ; C07D403/14 ; A61K31/40
摘要:
The present invention provides a method of treating thrombocytopenia, which comprises administering to a patient suffering from thrombocytopenia, an effective amount of an indolocarbazole derivative represented by formula (I):
wherein R¹ represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group or a tetrahydropyranyl group; R 2A and R 3A , which may be the same or different, each represent a hydrogen atom, a substituted or unsubstituted lower alkyl group, a lower alkenyl group, a substituted or unsubstituted aralkyl group or a monosaccharide residue where a hydroxyl group at the anomer position is removed; R 4A and R 5A , which may be the same or different, each represent a hydrogen atom, a formyl group, a hydroxyl group or a halogen atom; W A represents two hydrogen atoms or an oxygen atom; and X A represents a single bond or two hydrogen atoms, provided that when X A forms a single bond, then R¹, R 2A , R 3A , R 4A , R 5A , and W A do not simultaneously represent a hydrogen atom, or a pharmaceutically acceptable salt.
wherein R¹ represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group or a tetrahydropyranyl group; R 2A and R 3A , which may be the same or different, each represent a hydrogen atom, a substituted or unsubstituted lower alkyl group, a lower alkenyl group, a substituted or unsubstituted aralkyl group or a monosaccharide residue where a hydroxyl group at the anomer position is removed; R 4A and R 5A , which may be the same or different, each represent a hydrogen atom, a formyl group, a hydroxyl group or a halogen atom; W A represents two hydrogen atoms or an oxygen atom; and X A represents a single bond or two hydrogen atoms, provided that when X A forms a single bond, then R¹, R 2A , R 3A , R 4A , R 5A , and W A do not simultaneously represent a hydrogen atom, or a pharmaceutically acceptable salt.
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