发明公开
- 专利标题: GLYCEROL DERIVATIVE, DEVICE AND PHARMACEUTICAL COMPOSITION.
- 专利标题(中): 甘油的衍生物,设备和药物组合物。
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申请号: EP94907060申请日: 1994-02-17
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公开(公告)号: EP0685457A4公开(公告)日: 1996-09-18
- 发明人: YANO JUNICHI , OHGI TADAAKI
- 申请人: NIPPON SHINYAKU CO LTD
- 专利权人: NIPPON SHINYAKU CO LTD
- 当前专利权人: NIPPON SHINYAKU CO LTD
- 优先权: JP5493993 1993-02-19
- 主分类号: A61K31/70
- IPC分类号: A61K31/70 ; A61K9/127 ; A61K9/52 ; A61K9/66 ; A61K47/10 ; A61K47/24 ; A61K47/44 ; C07C229/06 ; C07C229/12 ; C07C237/08 ; C07C271/16 ; C07C271/20 ; C07C279/04 ; C07C279/20 ; C07C307/02 ; C07C333/04 ; C07D207/08 ; C07D211/08 ; C07D241/04 ; C07D265/30 ; C07D295/13 ; C07F9/40
摘要:
The invention aims at providing a device comprising lipids that act like the so-called cationic liposome and are reduced in toxicity and the lipids as the constituent of the device. The invention compounds are exemplified by 3-0-(4-dimethylaminobutanoyl)-1,2-0-dioleylglycerol, 3-0-(2-dimethylaminoethyl)carbamoyl-1,2-0-dioleylglycerol, 3-0-(2-diethylaminoethyl)carbamoyl-1,2-0-dioleylglycerol, and 2-0-(2-diethylaminoethyl)-carbamoyl-1,3-0-dioleylglycerol. The device comprises these lipids and phospholipids. The device enables, when administered together with, for example, a double-stranded RNA, the RNA to migrate to the action site safely.
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