发明授权
EP0686044B1 INHIBITION OF INTIMAL HYPERPLASIA USING ANTIBODIES TO PDGF RECEPTORS
失效
抗体PDGF受体素抑制内膜增生USE
- 专利标题： INHIBITION OF INTIMAL HYPERPLASIA USING ANTIBODIES TO PDGF RECEPTORS
- 专利标题（中）： 抗体PDGF受体素抑制内膜增生USE
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申请号： EP94909627.5申请日： 1994-02-17
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公开(公告)号： EP0686044B1公开(公告)日： 1998-09-02
- 发明人: HART, Charles E. , KENAGY, Richard D. , CLOWES, Alexander W.
- 申请人： ZymoGenetics, Inc. , THE UNIVERSITY OF WASHINGTON
- 申请人地址： 1201 Eastlake Avenue East Seattle, WA 98102 US
- 专利权人： ZymoGenetics, Inc.,THE UNIVERSITY OF WASHINGTON
- 当前专利权人： ZymoGenetics, Inc.,THE UNIVERSITY OF WASHINGTON
- 当前专利权人地址： 1201 Eastlake Avenue East Seattle, WA 98102 US
- 代理机构： Jorgensen, Dan
- 优先权： US23504 19930225
- 国际公布： WO9419016 19940901
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
Methods of inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal an anti-PDGF receptor antibody, such as an anti-PDGF-alpha receptor antibody or an anti-PDGF-beta receptor antibody. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft.
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