发明公开
EP0688319A1 4-HYDROXY-3-NITRO-1,2-DIHYDROQUINOLIN-2-ONES AND THE USE THEREOF AS EXCITATORY AMINO ACID AND GLYCINE RECEPTOR ANTAGONISTS
失效
4-羟基-3-硝基-1,2-二氢喹啉-2-酮及其作为兴奋性氨基酸和甘氨酸受体拮抗剂
- 专利标题： 4-HYDROXY-3-NITRO-1,2-DIHYDROQUINOLIN-2-ONES AND THE USE THEREOF AS EXCITATORY AMINO ACID AND GLYCINE RECEPTOR ANTAGONISTS
- 专利标题（中）： 4-羟基-3-硝基-1,2-二氢喹啉-2-酮及其作为兴奋性氨基酸和甘氨酸受体拮抗剂
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申请号： EP94911574.0申请日： 1994-03-11
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公开(公告)号： EP0688319A1公开(公告)日： 1995-12-27
- 发明人: CAI, Sui, Xiong , WEBER, Eckard , KEANA, John, F., W.
- 申请人： STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 申请人地址： THE OREGON HEALTH SCIENCES UNIVERSITY PORTLAND, OREGON, and THE UNIVERSITY OF OREGON, EUGENE, OREGON, Johnson Hall, University of Oregon Eugene, OR 97 US
- 专利权人： STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of,THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 当前专利权人： STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of,THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- 当前专利权人地址： THE OREGON HEALTH SCIENCES UNIVERSITY PORTLAND, OREGON, and THE UNIVERSITY OF OREGON, EUGENE, OREGON, Johnson Hall, University of Oregon Eugene, OR 97 US
- 代理机构： White, Martin Paul, et al
- 优先权： US19930030608 19930312; US19930101244 19930802
- 国际公布： WO1994020470 19940915
- 主分类号： A61K31
- IPC分类号： A61K31 ; A61P9 ; A61P25 ; C07D215
摘要：
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions and inducing anesthesia are disclosed by administering to an amimal in need of such treatment a substituted or unsubstituted 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-one or pharmaceutically acceptable salts thereof which have high binding to the glycine receptor.
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