发明授权
EP0690850B1 2-SUBSTITUTED MORPHOLINE AND THIOMORPHOLINE DERIVATIVES AS GABA-B ANTAGONISTS
失效
2-取代的吗啉和硫代吗啉AS GABA-B拮抗剂
- 专利标题： 2-SUBSTITUTED MORPHOLINE AND THIOMORPHOLINE DERIVATIVES AS GABA-B ANTAGONISTS
- 专利标题（中）： 2-取代的吗啉和硫代吗啉AS GABA-B拮抗剂
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申请号： EP94911608.1申请日： 1994-03-23
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公开(公告)号： EP0690850B1公开(公告)日： 1997-11-12
- 发明人: KUO, Shen-Chun , BLYTHIN, David, J. , KREUTNER, William
- 申请人： SCHERING CORPORATION
- 申请人地址： 2000 Galloping Hill Road Kenilworth New Jersey 07033 US
- 专利权人： SCHERING CORPORATION
- 当前专利权人： SCHERING CORPORATION
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth New Jersey 07033 US
- 代理机构： Ritter, Stephen David
- 优先权： US38584 19930326
- 国际公布： WO9422843 19941013
- 主分类号： C07D265/30
- IPC分类号： C07D265/30 ; C07D279/12 ; C07D265/34 ; C07F9/6533 ; A61K31/535 ; A61K31/54
摘要：
Disclosed are compounds of Formula (I) wherein: Y represents -CO2H, -CO2R6, -C(O)NHR7, -SO2H, -SO3H, -SO3R6, -SO2NHR7, -C(O)-N(OH)-R8, or a group of formula (a), (b), (c), (d) or (e); or a pharmaceutically acceptable addition salt or solvate thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula (I). Further disclosed is a method for treating or preventing respiratory depression, epileptic seizures or other central nervous system disorders, and for enhancing cognitive performance, by administering an effective amount of a compound of Formula (I).
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