发明授权
EP0708647B1 COMBINATION OF A PROGESTATIONAL AGENT AND A NITRIC OXIDE SYNTHASE SUBSTRATE AND/OR DONOR FOR THE TREATMENT OF PREECLAMPSIA AND PRETERM LABOR
失效
组合物先兆子痫和早期出生到PROGESTATIVES剂处理和氮氧化物合酶衬底和/或供体CONTAINS
- 专利标题： COMBINATION OF A PROGESTATIONAL AGENT AND A NITRIC OXIDE SYNTHASE SUBSTRATE AND/OR DONOR FOR THE TREATMENT OF PREECLAMPSIA AND PRETERM LABOR
- 专利标题（中）： 组合物先兆子痫和早期出生到PROGESTATIVES剂处理和氮氧化物合酶衬底和/或供体CONTAINS
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申请号： EP94924261.4申请日： 1994-07-18
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公开(公告)号： EP0708647B1公开(公告)日： 2000-05-10
- 发明人: GARFIELD, Robert E. , YALLAMPALLI, Chandra , CHWALISZ, Kristof, Dr. , BUKOWSKI, Radoslaw, Dr.
- 申请人： SCHERING AKTIENGESELLSCHAFT , GARFIELD, Robert , Yallampalli, Chandra
- 申请人地址： Müllerstrasse 170/178 13353 Berlin DE
- 专利权人： SCHERING AKTIENGESELLSCHAFT,GARFIELD, Robert,Yallampalli, Chandra
- 当前专利权人： SCHERING AKTIENGESELLSCHAFT,GARFIELD, Robert,Yallampalli, Chandra
- 当前专利权人地址： Müllerstrasse 170/178 13353 Berlin DE
- 优先权： US92426 19930716
- 国际公布： WO9502408 19950126
- 主分类号： A61K31/57
- IPC分类号： A61K31/57
摘要：
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclooxygenase inhibitor, a PGI2-mimetic, a thromboxane (TXA2) inhibitor, a compound possessing TXA2-agonistic and TXA2-inhibiting properties, a compound possessing TXA2-antagonistic and PGI2-memetic activities, and a TXA2 antagonist.
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