发明公开
- 专利标题： Carboxyalkyl heterocyclic derivatives
- 专利标题（中）： 杂环碳原子
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申请号： EP95120208.4申请日： 1995-12-20
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公开(公告)号： EP0718290A1公开(公告)日： 1996-06-26
- 发明人: Kotani, Takayuki, c/o Inst. of Bio-Active Science , Okamoto, Kaoru, c/o Inst. of Bio-Active Science , Nagaki, Yasuhiro, c/o Inst. of Bio-Active Science
- 申请人： NIPPON ZOKI PHARMACEUTICAL CO., LTD.
- 申请人地址： 1-2, Hiranomachi Nichome Chuo-ku, Osaka JP
- 专利权人： NIPPON ZOKI PHARMACEUTICAL CO., LTD.
- 当前专利权人： NIPPON ZOKI PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 1-2, Hiranomachi Nichome Chuo-ku, Osaka JP
- 代理机构： Hansen, Bernd, Dr. Dipl.-Chem.
- 优先权： JP335821/94 19941220
- 主分类号： C07D233/96
- IPC分类号： C07D233/96 ; C07D233/72 ; C07D233/66 ; C07D239/22 ; C07D417/06 ; A61K31/415 ; A61K31/425 ; A61K31/505
摘要：
A compound is provided represented by the following general formula (A)
wherein two of R a , R b and R c are oxygen; X is a kind of benzyl, a kind of benzothiazolylmethyl, or a kind of naphthylmethyl; R is hydrogen or lower alkyl; n is an integer of 1 to 3; and Z indicates a direct bond or a bridging moiety containing one carbon atom.
The compounds act as selective inhibitors of aldose reductase. The compounds provided are useful as drugs for therapy and prevention of various types of diabetic complications.
wherein two of R a , R b and R c are oxygen; X is a kind of benzyl, a kind of benzothiazolylmethyl, or a kind of naphthylmethyl; R is hydrogen or lower alkyl; n is an integer of 1 to 3; and Z indicates a direct bond or a bridging moiety containing one carbon atom.
The compounds act as selective inhibitors of aldose reductase. The compounds provided are useful as drugs for therapy and prevention of various types of diabetic complications.
公开/授权文献
- EP0718290B1 Carboxyalkyl heterocyclic derivatives 公开/授权日：2002-04-17
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