A device for controlling the process (1) of at least one actuator, operatively connectable to a flexible programming station (2), comprises a central microprocessor unit (CPU) (5), at least one first programmable and erasable memory unit (8), updatable during operations, and a second permanent memory unit (6), both operatively connected to the central microprocessor unit (5). The second memory unit (6) contains only a communication program capable of establishing a communication procedure between the device (1) and the programming station (2) so that in the first memory unit (8) a main control program in machine language generated in said programming station (2) to command the operation of at least one driver (11, 11A-11E) of an actuator is memorized.