发明授权
- 专利标题: PHARMACEUTICAL FORMULATIONS OF NERVE GROWTH FACTOR
- 专利标题(中): 药物制剂神经生长因子
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申请号: EP94925903.0申请日: 1994-08-16
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公开(公告)号: EP0721343B1公开(公告)日: 2002-10-16
- 发明人: KNEPP, Victoria M. , LIDGATE, Deborah M. , MASKIEWICZ, Richard , GU, Leo
- 申请人: Syntex (U.S.A.) LLC
- 申请人地址: 3401 Hillview Avenue Palo Alto, California 94304 US
- 专利权人: Syntex (U.S.A.) LLC
- 当前专利权人: Syntex (U.S.A.) LLC
- 当前专利权人地址: 3401 Hillview Avenue Palo Alto, California 94304 US
- 代理机构: Braun, Axel
- 优先权: US109798 19930820
- 国际公布: WO95005845 19950302
- 主分类号: A61K38/18
- IPC分类号: A61K38/18 ; A61K9/08 ; A61K9/19
摘要:
Stable, aqueous pharmaceutical formulations of human nerve growth factor (NGF) in aqueous isotonic solutions, buffered to maintain the pH from about 4.5 to about 6.0, and optionnally containing a carrier such as human serum albumin are provided. Also provided are aqueous NGF formulations suitable for lyophilization and subsequent reconstitution in which rhNGF is admixed with sugars, optionally HSA, and buffer. The formulations are useful for the treatment of Alzheimer's disease and other neuronal disorders.
公开/授权文献
- EP0721343A1 PHARMACEUTICAL FORMULATIONS OF NERVE GROWTH FACTOR 公开/授权日:1996-07-17
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