A wrist rest (10) for use in front of a computer keyboard, pointing device, typewriter or any other device requiring repetitive motion functions manually performed by an operator, has at least two parallel elongated chambers or sleeves filled with a pliant, deformable material upon which the wrists or hands of the user may rest. In use, the parallel sections prevent the wrist rest from rolling toward or away from the keyboard, and prevent the deformable material from bulging unduly under the thumbs of the user whose hands are placed upon the wrist rest. In one embodiment, a fabric cover has two elongated parallel pockets (24,25) into which sealed tubes (26,27) filled with deformable material are inserted. A flap (22) covers the open end of the pockets to prevent the tubes from escaping. In another embodiment, an inner impermeable elongated pouch is contained within an outer fabric pouch and parallel chambers are formed by running seals longitudinally along and between the pouches as well as along both ends.