发明公开
EP0743293A1 Process for producing biaryl compound
失效
Verfahren zur Herstellung von Biarylverbindungen
- 专利标题： Process for producing biaryl compound
- 专利标题（中）： Verfahren zur Herstellung von Biarylverbindungen
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申请号： EP96107781.5申请日： 1996-05-15
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公开(公告)号： EP0743293A1公开(公告)日： 1996-11-20
- 发明人: Shibata, Koichi , Matsui, Shuichi , Miyazawa, Kazutoshi
- 申请人： CHISSO CORPORATION
- 申请人地址： 6-32, Nakanoshima 3-chome Kita-ku Osaka-shi Osaka JP
- 专利权人： CHISSO CORPORATION
- 当前专利权人： CHISSO CORPORATION
- 当前专利权人地址： 6-32, Nakanoshima 3-chome Kita-ku Osaka-shi Osaka JP
- 代理机构： Hansen, Bernd, Dr. Dipl.-Chem.
- 优先权： JP141117/95 19950515; JP219592/95 19950804
- 主分类号： C07B37/04
- IPC分类号： C07B37/04
摘要：
A novel process for producing a biaryl compound represented by formula (III), which is useful as a medicine, an agricultural chemical and an electrooptical liquid-crystal display material:
Ar-Ar' (III)
(wherein Ar and Ar' each independently represents a substituted or unsubstituted aromatic group) which comprises the steps of (i) reacting a trialkoxysilyl-substituted aromatic compound represented by formula (I):
Ar-Si(OR) 3 (I)
(wherein Ar has the same meaning as defined above and R represents an alkyl group having from 1 to 5 carbon atoms) with a fluoride ion source in the presence of a solvent, and then (ii) adding thereto an aromatic compound represented by formula (II):
X-Ar' (II)
(wherein X represents an eliminating group and Ar' has the same meaning as defined above) and a catalyst comprising a transition metal of tenth group to conduct a further reaction.
Ar-Ar' (III)
(wherein Ar and Ar' each independently represents a substituted or unsubstituted aromatic group) which comprises the steps of (i) reacting a trialkoxysilyl-substituted aromatic compound represented by formula (I):
Ar-Si(OR) 3 (I)
(wherein Ar has the same meaning as defined above and R represents an alkyl group having from 1 to 5 carbon atoms) with a fluoride ion source in the presence of a solvent, and then (ii) adding thereto an aromatic compound represented by formula (II):
X-Ar' (II)
(wherein X represents an eliminating group and Ar' has the same meaning as defined above) and a catalyst comprising a transition metal of tenth group to conduct a further reaction.
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