发明公开
EP0749434A1 BENZOTHIOPHENE, BENZOFURAN AND INDOLETHIAZEPINONES, OXAZEPINONES AND DIAZEPINONES AS INHIBITORS OF CELL ADHESION AND AS INHIBITORS OF HIV
失效
苯并噻吩，苯并呋喃和吲哚THIAZEPINONE，OXAZEPINONE和二氮杂酮细胞粘附和艾滋病毒抑制剂
- 专利标题： BENZOTHIOPHENE, BENZOFURAN AND INDOLETHIAZEPINONES, OXAZEPINONES AND DIAZEPINONES AS INHIBITORS OF CELL ADHESION AND AS INHIBITORS OF HIV
- 专利标题（中）： 苯并噻吩，苯并呋喃和吲哚THIAZEPINONE，OXAZEPINONE和二氮杂酮细胞粘附和艾滋病毒抑制剂
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申请号： EP95908760.0申请日： 1995-01-30
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公开(公告)号： EP0749434A1公开(公告)日： 1996-12-27
- 发明人: BOSCHELLI, Diane, Harris , CONNOR, David, Thomas , KRAMER, James, Bernard , UNANGST, Paul, Charles
- 申请人： WARNER-LAMBERT COMPANY
- 申请人地址： 201 Tabor Road Morris Plains New Jersey 07950 US
- 专利权人： WARNER-LAMBERT COMPANY
- 当前专利权人： WARNER-LAMBERT COMPANY
- 当前专利权人地址： 201 Tabor Road Morris Plains New Jersey 07950 US
- 代理机构： Tesch, Rudolf, Dr., et al
- 优先权： US19940207330 19940307; US19940351611 19941212
- 国际公布： WO1995024408 19950914
- 主分类号： C07D487
- IPC分类号： C07D487 ; A61K31 ; A61P29 ; A61P31 ; A61P37 ; C07D495 ; C07D498 ; C07D513
摘要：
Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones of formula (I) as well as methods of preparation thereof are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases; these compounds also inhibit the activation of human immunodeficiency virus (HIV).
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