- 专利标题: ACID AMIDE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
- 专利标题(中): 乙酰胺和方法及其
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申请号: EP95918107.0申请日: 1995-05-18
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公开(公告)号: EP0759910A1公开(公告)日: 1997-03-05
- 发明人: RIVO, Endre , VIZI, E., Szilveszter , MAKARA, Gábor , REITER, J(RTM)zsef , BLASKO, Gábor , SIMIG, Gyula , GAAL, Lászlo , FEKETE, Márton
- 申请人: EGIS GYOGYSZERGYAR RT.
- 申请人地址: Kereszturi ut 30-38 H-1106 Budapest HU
- 专利权人: EGIS GYOGYSZERGYAR RT.
- 当前专利权人: EGIS GYOGYSZERGYAR RT.
- 当前专利权人地址: Kereszturi ut 30-38 H-1106 Budapest HU
- 代理机构: Pochart, François, et al
- 优先权: HU19940001522 19940518
- 国际公布: WO1995031443 19951123
- 主分类号: C07D413
- IPC分类号: C07D413 ; A61K31 ; A61P21 ; A61P25 ; C07D241
摘要:
The invention relates to new acid amide derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said acid amide derivatives for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The new compounds according to the invention can be characterized by formula (I), wherein R1 represents hydrogen or nitro, R?2 and R3¿ stand, independently from each other, for hydrogen, lower alkyl or lower alkenyl optionally carrying a substituent selected from the group consisting of halogen, hydroxy, lower alkoxy, di(lower alkyl)amino, phenyl-lower alkoxycarbonyl and a 5- to 6-membered saturated heteroring containing 1 or 2 nitrogen and/or oxygen atom(s); or R?2 and R3¿ form, together with the adjacent nitrogen atom, a 6-membered saturated heterocyclic group containing optionally 1 or 2 additional nitrogen atoms and/or oxygen atom(s), said ring optionally carrying a hydroxy or a hydroxy-lower alkyl group, and possess valuable AMPA and kainate antagonizing properties, so they can be used to advantage in the therapy.
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