发明公开
EP0771794A1 OXYGEN-CONTAINING HETEROCYCLIC COMPOUNDS
失效
SAUERSTOFF ENTHALTENDE HETEROCYCLISCHE VERBINDUNGEN
- 专利标题： OXYGEN-CONTAINING HETEROCYCLIC COMPOUNDS
- 专利标题（中）： SAUERSTOFF ENTHALTENDE HETEROCYCLISCHE VERBINDUNGEN
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申请号： EP96915194.3申请日： 1996-05-20
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公开(公告)号： EP0771794A1公开(公告)日： 1997-05-07
- 发明人: KAWAKITA, Takashi , OHSHIMA, Etsuo , YANAGAWA, Koji , IIDA, Kyoichiro , KOIKE, Rie , ICHIMURA, Michio , MANABE, Haruhiko , OHMORI, Kenji , SUZUKI, Fumio , NAKASATO, Yoshisuke
- 申请人： KYOWA HAKKO KOGYO CO., LTD.
- 申请人地址： Ohtemachi Bldg., 6-1, Ohtemachi I-chome Chiyoda-ku, Tokyo 100 JP
- 专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址： Ohtemachi Bldg., 6-1, Ohtemachi I-chome Chiyoda-ku, Tokyo 100 JP
- 代理机构： Casalonga, Axel
- 优先权： JP121537/95 19950519; JP258651/95 19951005
- 国际公布： WO9636624 19961121
- 主分类号： C07D307/80
- IPC分类号： C07D307/80 ; C07D307/94 ; C07D405/06 ; C07D405/10 ; C07D405/12
摘要：
An oxygen-containing heterocyclic compound represented by following Formula (I):
wherein R 1 and R 2 independently represent hydrogen, lower alkyl, cyano, -(CH 2 ) n -E-CO-F (wherein E represents a bond, O, or NH; F represents OR 6 or NR 7 R 8 ; and n represents an integer of 0 to 4), or the like; R 1 and R 2 are combined to represent a saturated carbon ring together with a carbon atom adjacent thereto; or R 2 , and R 11 or R 13 described below are combined to form a single bond; R 3 represents hydrogen, phenyl, or halogen; R 4 represents hydroxy, lower alkoxy, or the like; A represents -C(R 9 )(R 10 )- or O; B represents O, NR 11 , -C(R 12 )(R 13 )-, or -C(R 14 )(R 15 )-C(R 16 )(R 17 )-; D represents (i) -C(R 18 )(R 19 )-X- (wherein X represents -C(R 21 )(R 22 )-, S, or NR 23 ), (ii) -C(R 19a )=Y- [Y represents -C(R 24 )-Z- (wherein Z represents CONH, CONHCH 2 , or a bond), or N], or (iii) a bond; and R 5 represents aryl, an aromatic heterocyclic group, cycloalkyl, pyridine-N-oxide, cyano, or lower alkoxycarbonyl; or a pharmaceutically acceptable salt thereof.
wherein R 1 and R 2 independently represent hydrogen, lower alkyl, cyano, -(CH 2 ) n -E-CO-F (wherein E represents a bond, O, or NH; F represents OR 6 or NR 7 R 8 ; and n represents an integer of 0 to 4), or the like; R 1 and R 2 are combined to represent a saturated carbon ring together with a carbon atom adjacent thereto; or R 2 , and R 11 or R 13 described below are combined to form a single bond; R 3 represents hydrogen, phenyl, or halogen; R 4 represents hydroxy, lower alkoxy, or the like; A represents -C(R 9 )(R 10 )- or O; B represents O, NR 11 , -C(R 12 )(R 13 )-, or -C(R 14 )(R 15 )-C(R 16 )(R 17 )-; D represents (i) -C(R 18 )(R 19 )-X- (wherein X represents -C(R 21 )(R 22 )-, S, or NR 23 ), (ii) -C(R 19a )=Y- [Y represents -C(R 24 )-Z- (wherein Z represents CONH, CONHCH 2 , or a bond), or N], or (iii) a bond; and R 5 represents aryl, an aromatic heterocyclic group, cycloalkyl, pyridine-N-oxide, cyano, or lower alkoxycarbonyl; or a pharmaceutically acceptable salt thereof.
公开/授权文献
- EP0771794B1 OXYGEN-CONTAINING HETEROCYCLIC COMPOUNDS 公开/授权日：2006-05-03
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