发明授权
EP0775157B1 HUMAN SERUM ALBUMIN-PORPHYRIN COMPLEXES WITH THE ABILITY TO BIND OXYGEN AND THERAPEUTIC USES THEREOF
失效
从复杂卟啉与HSA结合的能力氧气，以及它们的治疗用途
- 专利标题： HUMAN SERUM ALBUMIN-PORPHYRIN COMPLEXES WITH THE ABILITY TO BIND OXYGEN AND THERAPEUTIC USES THEREOF
- 专利标题（中）： 从复杂卟啉与HSA结合的能力氧气，以及它们的治疗用途
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申请号： EP95926627.1申请日： 1995-07-07
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公开(公告)号： EP0775157B1公开(公告)日： 2001-10-31
- 发明人: BONAVENTURA, Joseph
- 申请人： DUKE UNIVERSITY
- 申请人地址： 001 Allen Building, Flowers Drive Durham, NC 27706 US
- 专利权人： DUKE UNIVERSITY
- 当前专利权人： DUKE UNIVERSITY
- 当前专利权人地址： 001 Allen Building, Flowers Drive Durham, NC 27706 US
- 代理机构： Silveston, Judith
- 优先权： US279371 19940722
- 国际公布： WO9603426 19960208
- 主分类号： C07K1/32
- IPC分类号： C07K1/32 ; C07K14/765
摘要：
The invention is directed to human serum albumin-porphyrin (HSA-P) complexes which are capable of reversible oxygen binding and their uses. These complexes may be used in applications requiring physiological oxygen carriers such as in blood substitute solutions, or in applications requiring plasma expanders. Methods for the production of these complexes are provided. In a specific example, HSA-P complexes are shown to exhibit reversible oxygen binding. In another example, the HSA-P complex does not exhibit appreciable vasoactivity.
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