发明授权
EP0789554B1 METHOD OF MAKING POLYHYDRIC ALCOHOL SOLUTIONS OF ENHANCED EFFICACY ANTIPERSPIRANT ACTIVES
失效
PROCESS SOLUTIONS多元醇的止汗剂效率提高CONTAIN
- 专利标题: METHOD OF MAKING POLYHYDRIC ALCOHOL SOLUTIONS OF ENHANCED EFFICACY ANTIPERSPIRANT ACTIVES
- 专利标题(中): PROCESS SOLUTIONS多元醇的止汗剂效率提高CONTAIN
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申请号: EP95939000.6申请日: 1995-10-30
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公开(公告)号: EP0789554B1公开(公告)日: 1999-09-22
- 发明人: PROVANCAL, Stephen, J. , CARRILLO, Angel, L. , FLUHLER, Thomas, J. , ORYSZCZAK, Richard , SANE, Jayant, N.
- 申请人: THE GILLETTE COMPANY
- 申请人地址: Prudential Tower Building Boston, Massachusetts 02199 US
- 专利权人: THE GILLETTE COMPANY
- 当前专利权人: THE GILLETTE COMPANY
- 当前专利权人地址: Prudential Tower Building Boston, Massachusetts 02199 US
- 代理机构: Baillie, Iain Cameron
- 优先权: US333896 19941102; US397451 19950302
- 国际公布: WO9614052 19960517
- 主分类号: A61K7/38
- IPC分类号: A61K7/38
摘要:
The present invention comprises a process of preparing a solution of an enhanced efficacy aluminum antiperspirant salt in a polyhydric alcohol by (a) providing an aqueous solution consisting essentially of about 5 % to about 18 % by weight of an enhanced efficacy aluminum antiperspirant salt in water, the enhanced efficacy aluminum antiperspirant salt having been prepared in situ without having been dried to a solid powder; (b) mixing the aqueous solution with a sufficient amount of a liquid polyhydric alcohol to provide a mixed solution which has an antiperspirant salt to polyhydric alcohol ratio of about 1:4 to about 1.2:1; and (c) rapidly evaporating the water from the mixed solution under vacuum to provide a final liquid polyhydric alcohol solution containing about 20 to 50 % enhanced efficacy aluminum antiperspirant salt and about 2 to 16 % water, with the balance being polyhydric alcohol. An alkaline glycinate salt, such as sodium, potassium or zinc glycinate, may be added to the polyhydric alcohol prior to the addition of the antiperspirant salt solution in order to raise the pH of the recovered product to about 4.1 to 5.0.
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