发明公开
EP0790977A1 AMINE DERIVATIVES FOR TREATMENT OF SKIN DISORDERS
失效
AMIN-DERIVATEFÜRDIE BEHANDLUNG VON HAUTERKRANKUNGEN
- 专利标题: AMINE DERIVATIVES FOR TREATMENT OF SKIN DISORDERS
- 专利标题(中): AMIN-DERIVATEFÜRDIE BEHANDLUNG VON HAUTERKRANKUNGEN
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申请号: EP95936755.0申请日: 1995-11-08
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公开(公告)号: EP0790977A1公开(公告)日: 1997-08-27
- 发明人: FUJIMORI, Taketoshi , KUSUOKU, Hiroshi , YAMAMURO, Akira , YADA, Yukihiro , HIGUCHI, Kazuhiko , IMOKAWA, Genji , KONDO, Naoki , MASUKAWA, Yoshinori , TOKUDA, Hajime , TSUJIMURA, Hisashi
- 申请人: Kao Corporation
- 申请人地址: 14-10, Nihonbashi Kayabacho 1-chome Chuo-Ku Tokyo 103 JP
- 专利权人: Kao Corporation
- 当前专利权人: Kao Corporation
- 当前专利权人地址: 14-10, Nihonbashi Kayabacho 1-chome Chuo-Ku Tokyo 103 JP
- 代理机构: Kindler, Matthias, Dr. Dipl.-Chem., et al
- 优先权: JP19940274874 19941109; JP19940274875 19941109
- 国际公布: WO1996015098 19960523
- 主分类号: A61K8
- IPC分类号: A61K8 ; A61K31 ; A61Q19 ; C07C217 ; C07D303
摘要:
An amine derivative represented by formula (1) or an acid addition salt thereof, wherein R1 represents a group (a), a cyclopentyl group, cyclohexyl group, or a cycloheptyl group, R2 is a hydrogen atom or C¿1?-C3 alkyl group which may be substituted by one or more hydroxy groups, m is an integer falling in the range from 3 to 5 inclusive, and n is an integer falling in the range from 9 to 11 inclusive. Also, intermediates useful in the manufacture of the amine derivative (1), compositions for external application to the skin containing the amine derivative, and keratinization improvers containing the amine derivative as an active component are described. The compound (1) has excellent keratinization improving action, pigmentation preventing action, etc.
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