发明授权
EP0804483B1 ISOLATED PEPTIDES DERIVED FROM MAGE TUMOR REJECTION ANTIGEN PRECURSORS WHICH COMPLEX WITH HLA-A2 MOLECULES
失效
衍生自与HLA-A2分子复合的肿瘤抑制性抗原前体的分离肽
- 专利标题： ISOLATED PEPTIDES DERIVED FROM MAGE TUMOR REJECTION ANTIGEN PRECURSORS WHICH COMPLEX WITH HLA-A2 MOLECULES
- 专利标题（中）： 衍生自与HLA-A2分子复合的肿瘤抑制性抗原前体的分离肽
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申请号： EP95914838.8申请日： 1995-03-22
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公开(公告)号： EP0804483B1公开(公告)日： 2000-12-27
- 发明人: TOWNSEND, Alan Molecular Immunology Group , BASTIN, Judy Molecular Immunology Group , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierrce , COULIE, Pierre , GAJEWSKI, Thomas , MELIEF, Cornelis J.M. , VISSEREN, M.W. , KAST, W.M.
- 申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD , RIJKSUNIVERSITEIT LEIDEN
- 申请人地址： 1345 Avenue of the Americas New York, New York 10105 US
- 专利权人： LUDWIG INSTITUTE FOR CANCER RESEARCH,THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD,RIJKSUNIVERSITEIT LEIDEN
- 当前专利权人： LUDWIG INSTITUTE FOR CANCER RESEARCH,THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD,RIJKSUNIVERSITEIT LEIDEN
- 当前专利权人地址： 1345 Avenue of the Americas New York, New York 10105 US
- 代理机构： Harrison Goddard Foote
- 优先权： US217186 19940324; US261160 19940617; US290381 19940815
- 国际公布： WO9525740 19950928
- 主分类号： C07K14/705
- IPC分类号： C07K14/705 ; C12N5/06 ; C07K16/28 ; A61K38/16 ; G01N33/576
摘要：
Tumor rejection antigens derived from MAGE tumor rejection precursors have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.
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