发明公开
- 专利标题： LIPOSOME WITH INCREASED RETENTION VOLUME
- 专利标题（中）： LIPOSOM MITERHÖHTEMRETENTIONSVOLUMEN
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申请号： EP95913349.7申请日： 1995-03-27
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公开(公告)号： EP0804925A1公开(公告)日： 1997-11-05
- 发明人: KIKUCHI, Hiroshi, Daiichi Pharmaceutical Co., Ltd. , YACHI, Kiyoto, Daiichi Pharmaceutical Co., Ltd.
- 申请人： DAIICHI PHARMACEUTICAL CO., LTD.
- 申请人地址： 14-10, Nihonbashi 3-chome Chuo-ku, Tokyo 103 JP
- 专利权人： DAIICHI PHARMACEUTICAL CO., LTD.
- 当前专利权人： DAIICHI PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 14-10, Nihonbashi 3-chome Chuo-ku, Tokyo 103 JP
- 代理机构： Kinzebach, Werner, Dr.
- 优先权： JP57409/94 19940328
- 国际公布： WO9526185 19951005
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K47/24 ; B01J13/02
摘要：
The present invention provides liposome preparations capable of efficiently holding water soluble substance particularly non-electrolytic water soluble substances.
Liposomes and suspensions thereof comprising multilamellar liposomes characterized in that the liposome membrane is formed from a neutral phospholipid comprising a substantially saturated fatty acid residue a charged phospholipid comprising a substantially saturated fatty acid residue, ratio of said neutral phospholipid and charged phospholipid is 200:1 to 3:1, weighted average particle size of the liposome is 50 nm to 3,000 nm, and an encapsulation capacity of the liposome (internal aqueous phase (volume)/lipids (weight)) is at least 5 mℓ/g.
The present liposome preparation can encapsulate an aqueous solution of a non-electrolytic water soluble substances with an encapsulation capacity (internal aqueous phase/lipids) of at least 5 mℓ/g.
Liposomes and suspensions thereof comprising multilamellar liposomes characterized in that the liposome membrane is formed from a neutral phospholipid comprising a substantially saturated fatty acid residue a charged phospholipid comprising a substantially saturated fatty acid residue, ratio of said neutral phospholipid and charged phospholipid is 200:1 to 3:1, weighted average particle size of the liposome is 50 nm to 3,000 nm, and an encapsulation capacity of the liposome (internal aqueous phase (volume)/lipids (weight)) is at least 5 mℓ/g.
The present liposome preparation can encapsulate an aqueous solution of a non-electrolytic water soluble substances with an encapsulation capacity (internal aqueous phase/lipids) of at least 5 mℓ/g.
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