发明公开
EP0822809A1 CONTROLLED RELEASE FORMULATION FOR WATER SOLUBLE DRUGS IN WHICH A PASSAGEWAY IS FORMED IN SITU
失效
FORWASSERLÖSLISCHE原料药控释制剂原位出口开口冷弯
- 专利标题: CONTROLLED RELEASE FORMULATION FOR WATER SOLUBLE DRUGS IN WHICH A PASSAGEWAY IS FORMED IN SITU
- 专利标题(中): FORWASSERLÖSLISCHE原料药控释制剂原位出口开口冷弯
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申请号: EP96908796.0申请日: 1996-03-13
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公开(公告)号: EP0822809A1公开(公告)日: 1998-02-11
- 发明人: CHEN, Chih-Ming , LEE, Der-Yang
- 申请人: ANDRX PHARMACEUTICALS, INC.
- 申请人地址: Suite 201, 4001 S.W. 47th Avenue Fort Lauderdale, FL 33314 US
- 专利权人: ANDRX PHARMACEUTICALS, INC.
- 当前专利权人: ANDRX PHARMACEUTICALS, INC.
- 当前专利权人地址: Suite 201, 4001 S.W. 47th Avenue Fort Lauderdale, FL 33314 US
- 代理机构: Gervasi, Gemma, Dr., et al
- 优先权: US19950431404 19950428
- 国际公布: WO1996033700 19961031
- 主分类号: A61K9
- IPC分类号: A61K9 ; A61K31
摘要:
A controlled release pharmaceutical tablet is disclosed which is based on: (a) a compressed core which contains: i) a medicament; ii) from 5 to 20 % by weight of a water soluble osmotic agent based on the total weight of the compressed core; iii) a water soluble pharmaceutically acceptable polymeric binder; iv) a conventional pharmaceutical excipient; and (b) a dual layer membrane coating around said core which consists essentially of: i) a first inner coating layer for sustained release of the medicament, said inner coating layer consisting essentially of a plasticized water insoluble pharmaceutically acceptable polymer and a pharmaceutically acceptable water soluble polymer, and; ii) a second outer coating layer for immediate release of a medicament, said outer coating layer consisting essentially of an effective amount of a medicament and a water soluble polymer. The controlled release formulation is suitable for the once-a-day administration of medicaments.
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