发明授权
EP0827547B1 RETROVIRUS VECTORS DERIVED FROM AVIAN SARCOMA LEUKOSIS VIRUSES PERMITTING TRANSFER OF GENES INTO MAMMALIAN CELLS AND THERAPEUTIC USES THEREOF
失效
从家禽SARCOM-白血病逆转录病毒载体能表达基因的SAEUGETIERZELLEN和治疗使用传送
- 专利标题： RETROVIRUS VECTORS DERIVED FROM AVIAN SARCOMA LEUKOSIS VIRUSES PERMITTING TRANSFER OF GENES INTO MAMMALIAN CELLS AND THERAPEUTIC USES THEREOF
- 专利标题（中）： 从家禽SARCOM-白血病逆转录病毒载体能表达基因的SAEUGETIERZELLEN和治疗使用传送
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申请号： EP96916528.1申请日： 1996-05-22
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公开(公告)号： EP0827547B1公开(公告)日： 2001-08-16
- 发明人: BARSOV, Eugene , HUGHES, Stephen, H.
- 申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 申请人地址： c/o National Institutes of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852-3804 US
- 专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： c/o National Institutes of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852-3804 US
- 代理机构： Vossius, Volker, Dr.
- 优先权： US445462 19950522
- 国际公布： WO9637625 19961128
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C12N15/62 ; C12N7/01 ; C12N5/10 ; A01K67/027 ; A61K39/21 ; A61K48/00
摘要：
Recombinant avian sarcoma leukosis virus (ASLV)-derived retrovirus vectors having an expanded host range are described. The host range is expanded by the replacement of the ASLV envelope gene by an envelope gene from a virus capable of infecting both mammalian and avian cells. The resulting recombinant ASLV-derived retroviral vectors can replicate efficiently in avian cells, infect both avian and mammalian cells in high titer, and are replication-defective in mammalian cells. Thus, they are quite safe and advantageous for use in gene therapy and vaccines.
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