- 专利标题： CIS-9,10-OCTADECENOAMIDASE
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申请号： EP96918507申请日： 1996-06-12
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公开(公告)号： EP0833899A4公开(公告)日： 2000-06-28
- 发明人: LERNER RICHARD A , CRAVATT BENJAMIN F , GILULA NORTON B
- 申请人： SCRIPPS RESEARCH INST
- 专利权人： SCRIPPS RESEARCH INST
- 当前专利权人： SCRIPPS RESEARCH INST
- 优先权： US48953595 1995-06-12
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; A61K31/12 ; A61P43/00 ; C07C45/45 ; C07C49/227 ; C07C57/03 ; C07C233/09 ; C07C327/22 ; C07F9/54 ; C12N9/80 ; C12N9/99 ; C12P7/64 ; C12N9/78 ; A61K38/46 ; C12N9/14
摘要：
The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary amides is neutralized by hydrolysis in the presence of cis-9,10-octadecenoamidase. Hydrolysis of cis-9,10-octadecenoamide leads to the formation of oleic acid, a compound without soporific activity. Inhibitors of cis-9,10-octadecenoamidase are disclosed to block this activity.
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