发明公开
EP0837057A1 Method of preparation of 4-hydroxy-1,2,2,6,6-pentamethylpiperidine
失效
Verfahren zur Herstellung von 4-羟基-1,2,2,6,6， - 五甲基哌啶
- 专利标题： Method of preparation of 4-hydroxy-1,2,2,6,6-pentamethylpiperidine
- 专利标题（中）： Verfahren zur Herstellung von 4-羟基-1,2,2,6,6， - 五甲基哌啶
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申请号： EP97308184.7申请日： 1997-10-15
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公开(公告)号： EP0837057A1公开(公告)日： 1998-04-22
- 发明人: Yasuda, Masaaki
- 申请人： Mitsui Chemicals, Inc.
- 申请人地址： 2-5, Kasumigaseki 3-chome, Chiyoda-ku Tokyo 100 JP
- 专利权人： Mitsui Chemicals, Inc.
- 当前专利权人： Mitsui Chemicals, Inc.
- 当前专利权人地址： 2-5, Kasumigaseki 3-chome, Chiyoda-ku Tokyo 100 JP
- 代理机构： Cresswell, Thomas Anthony
- 优先权： JP274753/96U 19961017; JP310386/96 19961121
- 主分类号： C07D211/46
- IPC分类号： C07D211/46
摘要：
A method for preparing 4-hydroxy-1,2,2,6,6-pentamethylpiperidine which method comprises the following steps:
(i) reacting 4-hydroxy-2,2,6,6-tetramethylpiperidine with a compound selected from formaldehyde, paraformaldehyde and trioxane, optionally in the presence of formic acid;
(ii) neutralising the reaction product obtained in step (i) by adding a base thereto to obtain a crude product and an aqueous layer; and
(iii) after the neutralisation, separating the crude product from the aqueous layer and crystallising and filtering the crude product to obtain crystals of 4-hydroxy-1,2,2,6,6-pentamethylpiperidine having a water content of 3% by weight or less.
(i) reacting 4-hydroxy-2,2,6,6-tetramethylpiperidine with a compound selected from formaldehyde, paraformaldehyde and trioxane, optionally in the presence of formic acid;
(ii) neutralising the reaction product obtained in step (i) by adding a base thereto to obtain a crude product and an aqueous layer; and
(iii) after the neutralisation, separating the crude product from the aqueous layer and crystallising and filtering the crude product to obtain crystals of 4-hydroxy-1,2,2,6,6-pentamethylpiperidine having a water content of 3% by weight or less.
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