发明授权
EP0839036B1 USE OF 1,4-DIHYDROPYRIDINE DERIVATIVES IN THE PREVENTION AND THERAPY OF ATHEROSCLEROTIC DEGRADATION OF ARTERIAL WALLS
失效
1,4-二氢吡啶衍生物的动脉壁中动脉粥样硬化变性的预防和治疗
- 专利标题： USE OF 1,4-DIHYDROPYRIDINE DERIVATIVES IN THE PREVENTION AND THERAPY OF ATHEROSCLEROTIC DEGRADATION OF ARTERIAL WALLS
- 专利标题（中）： 1,4-二氢吡啶衍生物的动脉壁中动脉粥样硬化变性的预防和治疗
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申请号： EP96924834.3申请日： 1996-06-28
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公开(公告)号： EP0839036B1公开(公告)日： 1999-08-25
- 发明人: SARTANI, Abraham , LEONARDI, Amedeo , TESTA, Rodolfo
- 申请人： RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY , RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.
- 申请人地址： Corso S. Gottardo 54 6830 Chiasso CH
- 专利权人： RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY,RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.
- 当前专利权人： RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY,RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.
- 当前专利权人地址： Corso S. Gottardo 54 6830 Chiasso CH
- 代理机构： SERJEANTS
- 优先权： ITMI951513 19950714
- 国际公布： WO9703669 19970206
- 主分类号： A61K31/44
- IPC分类号： A61K31/44
摘要：
1,4-Dihydropyridines have been found to counter several processes which play a role in the development of atherosclerotic vascular lesions, such as myocytes proliferation and migration, cholesterol metabolism in macrophages and oxidative modification of low density lipoproteins. They are therefore useful in the manufacture of medicaments for preventing, arresting and reversing atherosclerotic degradation in the arterial walls of humans. The preferred 1,4-dihydropyridines for this purpose are lercanidipine, (S)-lercanidipine and (R)-lercanidipine.
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