发明公开
- 专利标题: COMPOSES HETEROCYCLIQUES POUR LE TRAITEMENT DE L'ISCHEMIE MYOCARDIQUE
- 专利标题(英): Heterocyclic compounds for treating myocardial ischaemia
- 专利标题(中): 杂环化合物心肌缺血的治疗
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申请号: EP96927083.0申请日: 1996-07-25
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公开(公告)号: EP0842174A1公开(公告)日: 1998-05-20
- 发明人: RIEU, Jean-Pierre , PATOISEAU, Jean-François , JOHN, Gareth, W. , LEGRAND, Bruno , VALENTIN, Jean-Pierre
- 申请人: PIERRE FABRE MEDICAMENT
- 申请人地址: 45, Place Abel Gance 92100 Boulogne-Billancourt FR
- 专利权人: PIERRE FABRE MEDICAMENT
- 当前专利权人: PIERRE FABRE MEDICAMENT
- 当前专利权人地址: 45, Place Abel Gance 92100 Boulogne-Billancourt FR
- 代理机构: Ahner, Francis, et al
- 优先权: FR19950009079 19950726
- 国际公布: WO1997005134 19970213
- 主分类号: A61K31
- IPC分类号: A61K31 ; A61P9 ; C07D413 ; C07D417
摘要:
Novel substituted N-heterocyclyl-1-aryloxyalkyl-4-piperidineamines of formula (I), wherein each of R1 to R4, which are the same or different, is hydrogen, optionally branched C1-4 alkyl, optionally branched C1-4 alkyloxy, a halo grouping, a nitro grouping, a hydroxy grouping or a trifluoromethyl or trifluoromethoxyl grouping; R5 is hydrogen, optionally branched C1-6 alkyl, optionally branched C7-12 phenylalkyl optionally substituted on the aromatic by one or more radicals having the same definition as R1; W and X are oxygen or sulphur; Y is a C2-6 polymethylene grouping or a radical -CH2-CH(OH)-CH2-; and n is 0 or 1, are disclosed. Pure R or S isomers of said compounds, where applicable, as well as mixtures thereof, are also disclosed. Furthermore, therapeutically acceptable organic or inorganic salts of the compounds of general formula (I), and any hydrates thereof, are disclosed. Finally, a method for preparing the claimed compounds, and their use as drugs, are disclosed.
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