发明授权
EP0847450B1 MONO-ALLELIC MUTATION ANALYSIS FOR IDENTIFYING GERMLINE MUTATIONS
失效
MONO-等位基因突变分析及KEIMBAHMMUTATIONEN的检测
- 专利标题： MONO-ALLELIC MUTATION ANALYSIS FOR IDENTIFYING GERMLINE MUTATIONS
- 专利标题（中）： MONO-等位基因突变分析及KEIMBAHMMUTATIONEN的检测
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申请号： EP96930551.5申请日： 1996-08-23
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公开(公告)号： EP0847450B1公开(公告)日： 2003-11-05
- 发明人: VOGELSTEIN, Bert , KINZLER, Kenneth, W. , PAPADOPOULOS, Nickolas
- 申请人： THE JOHNS HOPKINS UNIVERSITY
- 申请人地址： 720 Rutland Avenue Baltimore, MD 21205-2109 US
- 专利权人： THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人： THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人地址： 720 Rutland Avenue Baltimore, MD 21205-2109 US
- 代理机构： Tombling, Adrian George
- 优先权： US519059 19950823
- 国际公布： WO97008341 19970306
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12P21/00 ; G01N33/50 ; G01N33/574 ; G01N33/68
摘要：
A diagnostic strategy for detection of inherited diseases caused by germline mutations is based on somatic cell hybridization. Each allele of a human gene involved in the inherited disease is isolated in a somatic cell hybrid. The products of the isolated human allele are then observed in the absence of the other allele of the human.
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